Kijlstra A, Jeurissen S H, Koning K M
Exp Eye Res. 1984 Jan;38(1):57-62. doi: 10.1016/0014-4835(84)90138-6.
Tears of various species were investigated for the presence of inhibitors of the complement system. Rat and mouse tears contained strong anti-complementary activity, whereas goat, guinea pig, rabbit and rhesus monkey gave approximately the same inhibition as human tears. The chicken and cat only contained weak anti-complementary activity. Further analysis of the complement inhibitors in rabbit tears by gel-filtration and SDS-PAGE suggests that a small tear protein (approximately 20 000 daltons) may be involved in the anti-complementary effect in this species. Studies concerning the mechanism of inhibition in rabbit tears show that the complement cascade is inhibited after the EAC14 intermediate has been formed. The fact that various species were shown to have complement inhibitors in their tear film now enables the investigation of the physiological role of these factors.
对各种动物的眼泪进行了补体系统抑制剂的检测。大鼠和小鼠的眼泪含有很强的抗补体活性，而山羊、豚鼠、兔子和恒河猴的眼泪产生的抑制作用与人类眼泪大致相同。鸡和猫的眼泪仅含有较弱的抗补体活性。通过凝胶过滤和SDS - PAGE对兔眼泪中的补体抑制剂进行进一步分析表明，一种小的泪液蛋白（约20000道尔顿）可能参与了该物种的抗补体作用。关于兔眼泪中抑制机制的研究表明，在EAC14中间体形成后补体级联反应受到抑制。现已证明各种动物的泪膜中都有补体抑制剂，这使得人们能够研究这些因子的生理作用。
