Bacal E, Patterson R
J Allergy Clin Immunol. 1978 Aug;62(2):72-5. doi: 10.1016/0091-6749(78)90081-7.
The average prednisone dosage of 54 corticosteroid-dependent asthmatics was computed for one year prior to initiation of beclomethasone dipropionate. This was compared to the average prednisone dosage after nine months on the beclomethasone with progressive tapering of prednisone to either dose compatible with control of asthma or discontinuation. Beclomethasone was found clinically useful in the great majority of these patients because it permitted a significant decrease in dosage of prednisone, a change from daily to alternate-day prednisone, or discontinuation of prednisone after cautious tapering. The first two advantages were most evident in those asthmatics who initially required higher doses of oral steroids while the latter was evident in those requiring lower doses. Those patients whose prednisone dosage does not appear to be beneficially affected by the use of beclomethasone should be suspect as to adherence to proper medical dosage schedule.
计算了54例依赖皮质类固醇的哮喘患者在开始使用二丙酸倍氯米松前一年的泼尼松平均剂量。将其与使用二丙酸倍氯米松9个月后泼尼松的平均剂量进行比较，同时逐渐减少泼尼松剂量，直至达到与哮喘控制或停药相适应的剂量。临床上发现，二丙酸倍氯米松对这些患者中的绝大多数都很有用，因为它能显著减少泼尼松的剂量，使泼尼松从每日服用改为隔日服用，或在谨慎减量后停用泼尼松。前两个优点在最初需要较高剂量口服类固醇的哮喘患者中最为明显，而后者在需要较低剂量的患者中较为明显。那些泼尼松剂量似乎未因使用二丙酸倍氯米松而受到有益影响的患者，应怀疑其是否遵守了正确的药物剂量方案。
