诺氏疟原虫：用配子抗原免疫的猴子中传播阻断免疫力的持久性。
Plasmodium knowlesi: persistence of transmission blocking immunity in monkeys immunized with gamete antigens.
作者信息
Gwadz R W, Koontz L C
出版信息
Infect Immun. 1984 Apr;44(1):137-40. doi: 10.1128/iai.44.1.137-140.1984.
Abstract
Eight rhesus monkeys immunized with a partially purified preparation of Plasmodium knowlesi gametes were monitored for over 6 years to determine the extent of transmission blocking immunity. Monkeys were challenged regularly, and anti-gamete antibodies were assayed by in vivo and in vitro mosquito feedings. Transmission blocking immunity persisted at high levels in most of the monkeys. In those animals in which protection waned between challenges, a challenge infection provided a sufficient booster effect to prevent infection of mosquitoes. Immunity to other stages of malaria (i.e., sporozoites and asexual erythrocyte forms) failed to induce immunity against gametes.
摘要
用部分纯化的诺氏疟原虫配子体制剂免疫8只恒河猴，对其进行了6年多的监测，以确定传播阻断免疫的程度。定期对猴子进行攻击，并通过体内和体外蚊子叮咬检测抗配子抗体。大多数猴子的传播阻断免疫维持在高水平。在那些攻击之间保护作用减弱的动物中，一次攻击感染提供了足够的增强作用，以防止蚊子感染。对疟疾其他阶段（即子孢子和无性红细胞形式）的免疫未能诱导针对配子的免疫。
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