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胰高血糖素对人、猪、兔和大鼠输尿管蠕动的影响。

Effect of glucagon on ureteric peristalsis in man, pig, rabbit and rat.

作者信息

Stower M J, Clark A G, Wright J W, Hardcastle J D

出版信息

J Urol. 1984 Apr;131(4):822-4. doi: 10.1016/s0022-5347(17)50632-1.

DOI:10.1016/s0022-5347(17)50632-1
PMID:6708206
Abstract

The effect of glucagon on ureteric peristalsis in man, pig, rabbit and rat has been studied using specially shaped perspex blocks containing silver/silver chloride bipolar electrodes. In all subjects the ureteric electrical activity was recorded during laparotomy. Glucagon was administered as a single intravenous dose of 14 micrograms per kilogram in man and in doses of between 6.25 and 160 micrograms per kilogram in the other species. The mean (+/- S.E.M.) peristaltic rates per minute were: man 4.85 (+/- 0.66), pig 2.04 (+/- 0.36), rabbit 3.78 (+/- 0.23) and rat 5.02 (+/- 0.16). Glucagon was found to have no significant effect on ureteric peristalsis in man, rabbit or rat, whilst in the pig a variable effect was seen.

摘要

使用含有银/氯化银双极电极的特殊形状有机玻璃块,研究了胰高血糖素对人、猪、兔和大鼠输尿管蠕动的影响。在所有受试对象中,均在剖腹手术期间记录输尿管电活动。在人身上,胰高血糖素以每千克14微克的单次静脉注射剂量给药,在其他物种中,给药剂量为每千克6.25至160微克。每分钟的平均(±标准误)蠕动频率分别为:人4.85(±0.66),猪2.04(±0.36),兔3.78(±0.23),大鼠5.02(±0.16)。发现胰高血糖素对人、兔或大鼠的输尿管蠕动没有显著影响,而在猪身上则观察到了可变的影响。

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