Zachara B, Gromadzińska J, Czernicki J, Maciejek Z, Chmielewski H
Klin Wochenschr. 1984 Feb 15;62(4):179-82. doi: 10.1007/BF01731641.
Glutathione peroxidase (GSH-Px) activity of red blood cells of 23 multiple sclerosis (MS) patients (10 men and 13 women, aged 22-64 years) was examined and compared to the enzyme activity of 26 healthy persons (15 men and 11 women, aged 19-50 years). It was found that the mean GSH-Px activity was significantly higher (P less than 0.001) in red blood cells of MS patients (39.1 +/- 8.1 IU/g Hb) as compared to the group of healthy persons (25.9 +/- 5.2 IU/g Hb). There was no difference according to sexes in both the MS patients and the control group. The results are discussed based on the hypothesis that organic peroxides play a role in the etiology of multiple sclerosis.
检测了23例多发性硬化症（MS）患者（10名男性和13名女性，年龄22 - 64岁）红细胞中的谷胱甘肽过氧化物酶（GSH - Px）活性，并与26名健康人（15名男性和11名女性，年龄19 - 50岁）的酶活性进行比较。结果发现，与健康人组（25.9±5.2 IU/g Hb）相比，MS患者红细胞中的平均GSH - Px活性显著更高（P＜0.001）（39.1±8.1 IU/g Hb）。MS患者组和对照组在性别上均无差异。基于有机过氧化物在多发性硬化症病因中起作用这一假设对结果进行了讨论。
