多发性硬化症中红细胞谷胱甘肽过氧化物酶活性降低。

Decreased erythrocyte glutathione peroxidase activity in multiple sclerosis.

作者信息

Szeinberg A, Golan R, Ben Ezzer J, Sarova-Pinhas I, Sadeh M, Braham J

出版信息

Acta Neurol Scand. 1979;60(5):265-71. doi: 10.1111/j.1600-0404.1979.tb02980.x.

DOI:10.1111/j.1600-0404.1979.tb02980.x

Abstract

The mean activity of glutathione peroxidase (GSH-PX) in erythrocytes of 22 Israel-Jewish patients with multiple sclerosis (19.3 +/- 4.5 U/gHb) was significantly lower than in a control group of 30 Jewish patients with various neurological disorders (24.3 +/- 5.1 U/gHb). This observation confirms a similar finding of a decreased activity of GSH-Px in erythrocytes of multiple sclerosis patients in Denmark (Shukla et al. 1977). These results are discussed in relation to the possibility of selenium deficiency and to the recently described genetic polymorphism and ethnic variation of GSH-Px activity in human red cells. It is concluded that additional investigations are required in order to elucidate the cause of the decreased activity of this enzyme in red cells of patients with multiple sclerosis.

摘要

22名患有多发性硬化症的以色列犹太患者红细胞中谷胱甘肽过氧化物酶（GSH-PX）的平均活性（19.3 +/- 4.5 U/gHb）显著低于30名患有各种神经系统疾病的犹太患者组成的对照组（24.3 +/- 5.1 U/gHb）。这一观察结果证实了丹麦多发性硬化症患者红细胞中GSH-Px活性降低的类似发现（Shukla等人，1977年）。这些结果结合硒缺乏的可能性以及最近描述的人类红细胞中GSH-Px活性的基因多态性和种族差异进行了讨论。得出的结论是，需要进一步调查以阐明多发性硬化症患者红细胞中该酶活性降低的原因。