Beno I, Volkovová K, Bátovsky M, Staruchová M
Research Institute of Nutrition, Bratislava, Slovak Republic.
Eur J Cancer Prev. 1993 Nov;2(6):461-5. doi: 10.1097/00008469-199311000-00005.
Gastroscopy with gastric biopsy was performed in 109 individuals aged 25-71 years. Activities of three antioxidant enzymes were assayed in biopsy specimens: Cu/Zn superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px). Patients were classified according to the endoscopic and histological findings in the following groups: normal findings (N), superficial gastritis (SG), mild (MAG) and severe (SAG) atrophic gastritis, gastritis after partial gastrectomy (PGG), hyperplastic polyp (HP), and gastric adenoma (A). Compared with the N group, increased activity of SOD was found in groups SG (+37%), PGG (+67%) and A (+35%), increased CAT activity in PGG (+40%), and increased GSH-Px activity in groups SG (+57%), SAG (+46%), PGG (+185%), HP (+50%) and A (+50%). Increased activity of antioxidant enzymes could be induced by higher concentrations of superoxide anion radicals, hydrogen peroxide and lipid peroxides, produced by phagocytic leucocytes or by polyunsaturated fatty acid in cellular membranes of gastric mucosa. The relation of reactive oxygen species to the induction of precancerous conditions and to carcinogenesis of the stomach requires further study.
对109名年龄在25至71岁之间的个体进行了胃镜检查及胃活检。在活检标本中检测了三种抗氧化酶的活性：铜/锌超氧化物歧化酶（SOD）、过氧化氢酶（CAT）和谷胱甘肽过氧化物酶（GSH-Px）。根据内镜和组织学检查结果，将患者分为以下几组：正常结果（N）、浅表性胃炎（SG）、轻度（MAG）和重度（SAG）萎缩性胃炎、部分胃切除术后胃炎（PGG）、增生性息肉（HP）和胃腺瘤（A）。与N组相比，SG组（+37%）、PGG组（+67%）和A组（+35%）的SOD活性增加，PGG组（+40%）的CAT活性增加，SG组（+57%）、SAG组（+46%）、PGG组（+185%）、HP组（+50%）和A组（+50%）的GSH-Px活性增加。抗氧化酶活性增加可能是由吞噬性白细胞或胃黏膜细胞膜中的多不饱和脂肪酸产生的较高浓度的超氧阴离子自由基、过氧化氢和脂质过氧化物诱导的。活性氧与胃癌前病变的诱导及胃癌发生之间的关系需要进一步研究。
