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Conformational changes in the chromatin of the brain of developing rats and its modulation by zinc chloride.

作者信息

Supakar P C, Kanungo M S

出版信息

Mol Biol Rep. 1984 Jan;9(4):253-7. doi: 10.1007/BF00775357.

DOI:10.1007/BF00775357
PMID:6708952
Abstract

Conformational changes in the chromatin of the brain were studied during the development of the rat (3-, 14- and 30-day old) using micrococcal nuclease (MCN) and DNase I. The rate and extent of digestion of chromatin by MCN is not altered during development. However, pre-incubation of slices of the cerebral cortex with ZnCl2 increases the initial rate of digestion by MCN by 2-3-fold, and also enhances the production of monomer DNA. The rate and extent of digestion of chromatin by DNase I is greater in an early stage of development. The initial rate of digestion by DNase I is stimulated by 3-4-fold after ZnCl2 treatment. These data show that changes occur in the conformation of chromatin, particularly in the internucleosomal region of brain cells as they pass from dividing to the non-dividing state.

摘要

相似文献

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J Cell Biol. 1981 Apr;89(1):78-85. doi: 10.1083/jcb.89.1.78.
2
Phosphorylation states of different histone 1 subtypes and their relationship to chromatin functions during the HeLa S-3 cell cycle.HeLa S-3细胞周期中不同组蛋白1亚型的磷酸化状态及其与染色质功能的关系。
Biochemistry. 1981 Mar 17;20(6):1445-54. doi: 10.1021/bi00509a007.
3
Cell-specific phosphorylation of H1 histone subtypes among different Chinese hamster cell lines in interphase.
间期不同中国仓鼠细胞系中H1组蛋白亚型的细胞特异性磷酸化。
J Biol Chem. 1982 Feb 10;257(3):1247-52.
4
Nucleosome structure.核小体结构。
Annu Rev Biochem. 1980;49:1115-56. doi: 10.1146/annurev.bi.49.070180.005343.
5
Phosphorylation of histones 1 and 3 and nonhistone high mobility group 14 by an endogenous kinase in HeLa metaphase chromosomes.HeLa中期染色体中内源性激酶对组蛋白1和3以及非组蛋白高迁移率族蛋白14的磷酸化作用。
J Biol Chem. 1982 Jun 10;257(11):6064-72.
6
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Biochim Biophys Acta. 1982 Feb 4;701(1):57-62. doi: 10.1016/0167-4838(82)90312-0.
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