Bardach J, Mooney M P
Plast Reconstr Surg. 1984 Apr;73(4):544-55. doi: 10.1097/00006534-198404000-00005.
In the present study with beagles, various states of lip pressure (decreased and increased) following surgical creation of the lip and palatal defects and subsequent lip repair were found to be significantly related to craniofacial growth aberrations and disproportions. These aberrations are discussed in terms of an imbalanced functional skeletal-soft-tissue matrix. Significantly elevated lip pressure following lip repair in group III animals was found to be more detrimental to craniofacial growth than decreased lip pressure resulting from the surgical creation of a defect left unrepaired. Results of the study present, for the first time, documented evidence of a significant relationship between lip pressure following lip repair and craniofacial growth. Caution should be employed in extending these conclusions to the clinical setting, yet the findings underscore the need for well-controlled clinical studies designed to assess the influence of cleft lip repair on craniofacial growth.
在本项针对比格犬的研究中，发现唇腭裂修复手术造成唇部和腭部缺损并随后进行唇部修复后，各种唇部压力状态（降低和升高）与颅面生长异常及比例失调显著相关。这些异常是根据功能骨骼-软组织基质失衡来讨论的。研究发现，III组动物唇部修复后显著升高的唇部压力对颅面生长的危害大于因手术造成缺损未修复而导致的唇部压力降低。该研究结果首次提供了唇部修复后唇部压力与颅面生长之间存在显著关系的文献证据。将这些结论推广至临床时应谨慎，但研究结果强调了开展精心控制的临床研究以评估唇裂修复对颅面生长影响的必要性。
