Poloni M, Cosi V, Scelsi R, Marchetti C, Moglia A, Rognone F, Piccolo G
Schweiz Arch Neurol Neurochir Psychiatr. 1984;134(1):41-52.
The authors describe the clinical and laboratory results relative to 7 cases of Ophthalmoplegia Plus, with special reference to the histochemical, ultra-structural and CFS findings and to the data obtained by Computerized Tomography (CT) of the brain. The CSF was altered in all the examined patients: 3 out of 7 presented an abnormal albumin quotient, 1 patient had an increased IgG Index; the isoelectrofocusing of the CSF proteins, carried out in 6 out of 7 cases, showed an abnormal protein content referred to gamma trace in 3 cases, oligoclonal bands in the CSF in one case, a double Tau fraction in one case, a damaged blood-brain barrier in 5 cases. The CT-performed in 6 out of 7 cases-revealed in one patient a diffuse hypodensity of the periventricular white matter, without signs of atrophy; 2 cases showed a mild atrophy of the posterior fossa involving the cerebellar hemispheres and vermis in one case, the vermis and the brain stem in the other one; no patient revealed signs of cortical or ventricular atrophy. The boundaries of the Ophthalmoplegia Plus are here discussed on the ground of the results obtained by the employment of the various research methods.
作者描述了7例眼肌麻痹综合征患者的临床和实验室检查结果，特别提及了组织化学、超微结构及脑脊液检查结果，以及脑部计算机断层扫描（CT）所获数据。所有接受检查的患者脑脊液均有改变：7例中有3例白蛋白商异常，1例免疫球蛋白G指数升高；7例中有6例进行了脑脊液蛋白质等电聚焦分析，结果显示，3例γ-微量蛋白含量异常，1例脑脊液中有寡克隆带，1例有双Tau组分，5例血脑屏障受损。7例中有6例进行了CT检查，其中1例显示脑室周围白质弥漫性低密度，无萎缩迹象；2例显示后颅窝轻度萎缩，1例累及小脑半球和蚓部，另1例累及蚓部和脑干；未发现有皮质或脑室萎缩迹象。基于采用各种研究方法所获结果，本文讨论了眼肌麻痹综合征的界定。
