Smith A L, Tignor G H, Mifune K, Motohashi T
Intervirology. 1977;8(2):92-9. doi: 10.1159/000148883.
Infection of CER cell cultures with field strains of rabies virus, ranging from 0 to 5 mouse brain passages, was detected by immunoflurescence within 2-4 days after infection. A fluorescent focus assay for measuring infectivity of seven rabies serogroup viruses was rapid and reproducible. Rabies field strians and other rabies serogroup viruses also induced cytopathic effect, usually on initial passage. The hemadsorption-negative (HAD-) plaque test in BSC-1 cells was successfully applied to laboratory-adapted rabies strains. HAD- test attempts were unsuccessful with CER cells and with field isolates of rabies virus in both cell lines. CER cells are heteroploid and are antigenically related to BHK-21 cells by fluorsecent antibody tests.
用传代0至5代小鼠脑的狂犬病病毒野毒株感染CER细胞培养物，在感染后2至4天通过免疫荧光法检测到感染。一种用于测量七种狂犬病血清群病毒感染性的荧光灶试验快速且可重复。狂犬病野毒株和其他狂犬病血清群病毒通常在初次传代时也会诱导细胞病变效应。BSC - 1细胞中的血吸附阴性（HAD -）蚀斑试验已成功应用于实验室适应的狂犬病毒株。在CER细胞以及两种细胞系中的狂犬病病毒野毒株分离物上进行HAD -试验均未成功。CER细胞是异倍体，通过荧光抗体试验与BHK - 21细胞有抗原相关性。
