Meddens M J, Thompson J, Mattie H, van Furth R
Antimicrob Agents Chemother. 1984 Feb;25(2):263-7. doi: 10.1128/AAC.25.2.263.
The contributions of granulocytes to the prevention and therapy of Streptococcus sanguis endocarditis with procaine benzylpenicillin (PBP) was investigated in rabbits. Depletion of granulocytes by treatment with mechlorethamine appeared to have no significant effect on either the prophylactic or therapeutic activities of PBP. Administration of 3,000 IU of PBP before inoculation with S. sanguis retarded the course of the endocarditis for only 24 h whether granulocytes were normal or depressed in numbers. Prophylaxis with either 15,000 or 30,000 IU of PBP was equally effective in non-granulocytopenic and granulocytopenic rabbits. Treatment of established infections with PBP at doses of 3,000 to 300,000 IU of PBP at 12-h intervals for 48 h was equally effective in rabbits with normal and depressed numbers of granulocytes. The effect of 3,000 IU of PBP was equivalent, however, to that of granulocytes alone, as shown by the fact that the numbers of CFU per gram of vegetation in the granulocytopenic rabbits treated with this dose of PBP and in the non-PBP-treated control rabbits were not significantly different.
在兔身上研究了粒细胞对普鲁卡因苄青霉素（PBP）预防和治疗血链球菌性心内膜炎的作用。用氮芥处理使粒细胞减少，这似乎对PBP的预防或治疗活性均无显著影响。在接种血链球菌之前给予3000 IU的PBP，无论粒细胞数量正常还是减少，心内膜炎病程仅延缓24小时。用15000或30000 IU的PBP进行预防，在非粒细胞减少和粒细胞减少的兔中同样有效。对已建立的感染，以3000至300000 IU的PBP每12小时给药一次，持续48小时进行治疗，在粒细胞数量正常和减少的兔中同样有效。然而，3000 IU的PBP的效果与单独的粒细胞相当，这一事实表明，用此剂量PBP治疗的粒细胞减少兔和未用PBP治疗的对照兔每克赘生物中的菌落形成单位数量无显著差异。
