在细菌性心内膜炎体外模型中对单核细胞组织因子表达的刺激。
Stimulation of monocyte tissue factor expression in an in vitro model of bacterial endocarditis.
作者信息
Bancsi M J, Thompson J, Bertina R M
机构信息
Department of Infectious Diseases, Leiden State University Hospital, The Netherlands.
出版信息
Infect Immun. 1994 Dec;62(12):5669-72. doi: 10.1128/iai.62.12.5669-5672.1994.
Abstract
The coagulation system plays a major role in the formation of the infected endocardial vegetation in bacterial endocarditis. Since monocytes can express tissue factor (TF) on their surfaces, they are thought to be responsible for the extrinsic activation of the coagulation cascade during this disease. The present study used an in vitro model in which fibrin plates, isolated adherent monocytes, and Streptococcus sanguis were used as an analog for endocardial vegetations. Adherence to fibrin by itself was found to stimulate TF expression on the monocytes, but stimulation by S. sanguis significantly increased TF expression, which was found to be maximal at a bacterium-to-monocyte ratio of 9 or more.
摘要
凝血系统在细菌性心内膜炎感染性心内膜赘生物的形成中起主要作用。由于单核细胞可在其表面表达组织因子（TF），因此它们被认为是该疾病期间凝血级联反应外源性激活的原因。本研究使用了一种体外模型，其中纤维蛋白平板、分离的黏附单核细胞和血链球菌被用作心内膜赘生物的类似物。发现单核细胞自身对纤维蛋白的黏附会刺激TF表达，但血链球菌的刺激会显著增加TF表达，且在细菌与单核细胞的比例为9或更高时发现TF表达达到最大值。
相似文献
1
Stimulation of monocyte tissue factor expression in an in vitro model of bacterial endocarditis.在细菌性心内膜炎体外模型中对单核细胞组织因子表达的刺激。
Infect Immun. 1994 Dec;62(12):5669-72. doi: 10.1128/iai.62.12.5669-5672.1994.
2
Role of phagocytosis in activation of the coagulation system in Streptococcus sanguis endocarditis.吞噬作用在血链球菌性心内膜炎凝血系统激活中的作用。
Infect Immun. 1996 Dec;64(12):5166-70. doi: 10.1128/iai.64.12.5166-5170.1996.
3
Role of monocytes in experimental Staphylococcus aureus endocarditis.单核细胞在实验性金黄色葡萄球菌性心内膜炎中的作用。
Infect Immun. 2000 Aug;68(8):4818-21. doi: 10.1128/IAI.68.8.4818-4821.2000.
4
Enhancement of generation of monocyte tissue thromboplastin by bacterial phagocytosis: possible pathway for fibrin formation on infected vegetations in bacterial endocarditis.细菌吞噬作用增强单核细胞组织凝血活酶的生成：细菌性心内膜炎感染赘生物上纤维蛋白形成的可能途径。
Infect Immun. 1979 Jul;25(1):388-95. doi: 10.1128/iai.25.1.388-395.1979.
5
Role of monocytes and bacteria in Staphylococcus epidermidis endocarditis.单核细胞和细菌在表皮葡萄球菌心内膜炎中的作用。
Infect Immun. 1998 Feb;66(2):448-50. doi: 10.1128/IAI.66.2.448-450.1998.
6
Procoagulant activity of endocardial vegetations and blood monocytes in rabbits with Streptococcus sanguis endocarditis.血链球菌性心内膜炎家兔心内膜赘生物及血液单核细胞的促凝活性
Thromb Haemost. 1989 Nov 24;62(3):1029-33.
7
Monocytes maintain tissue factor activity after cytolysis of bacteria-infected endothelial cells in an in vitro model of bacterial endocarditis.在细菌性心内膜炎的体外模型中，单核细胞在细菌感染的内皮细胞溶解后维持组织因子活性。
J Infect Dis. 2002 Oct 15;186(8):1145-54. doi: 10.1086/344231. Epub 2002 Sep 25.
8
Interleukin-10 regulates the tissue factor activity of monocytes in an in vitro model of bacterial endocarditis.白细胞介素-10在细菌性心内膜炎的体外模型中调节单核细胞的组织因子活性。
Infect Immun. 2001 May;69(5):3197-202. doi: 10.1128/IAI.69.5.3197-3202.2001.
9
Influence of monocytes and antibiotic treatment on tissue factor activity of endocardial vegetations in rabbits infected with Streptococcus sanguis.单核细胞和抗生素治疗对感染血链球菌的家兔心内膜赘生物组织因子活性的影响。
Infect Immun. 1996 Feb;64(2):448-51. doi: 10.1128/iai.64.2.448-451.1996.
10
Monocytes augment bacterial species- and strain-dependent induction of tissue factor activity in bacterium-infected human vascular endothelial cells.单核细胞增强细菌感染的人血管内皮细胞中组织因子活性的细菌种类和菌株依赖性诱导。
Infect Immun. 2001 May;69(5):2797-807. doi: 10.1128/IAI.69.5.2797-2807.2001.
引用本文的文献
1
Platelet depletion and severity of streptococcal endocarditis.血小板减少与链球菌性心内膜炎的严重程度
Can J Infect Dis. 1998 Nov;9(6):359-66. doi: 10.1155/1998/926783.
2
Platelets in defense against bacterial pathogens.血小板在抵御细菌病原体中的作用。
Cell Mol Life Sci. 2010 Feb;67(4):525-44. doi: 10.1007/s00018-009-0210-4. Epub 2009 Dec 15.
3
New concepts in the pathophysiology of infective endocarditis.感染性心内膜炎病理生理学的新概念。
Curr Infect Dis Rep. 2006 Jun;8(4):271-9. doi: 10.1007/s11908-006-0071-z.
4
Endocarditis-associated oral streptococci promote rapid differentiation of monocytes into mature dendritic cells.心内膜炎相关口腔链球菌促进单核细胞快速分化为成熟树突状细胞。
Infect Immun. 2005 Aug;73(8):5015-21. doi: 10.1128/IAI.73.8.5015-5021.2005.
5
Susceptibility to thrombin-induced platelet microbicidal protein is associated with increased fluconazole efficacy against experimental endocarditis due to Candida albicans.对凝血酶诱导的血小板杀菌蛋白的易感性与氟康唑对白色念珠菌所致实验性心内膜炎疗效增强相关。
Antimicrob Agents Chemother. 2004 Aug;48(8):3051-6. doi: 10.1128/AAC.48.8.3051-3056.2004.
6
Increased blood coagulation and platelet activation in patients with infective endocarditis and embolic events.感染性心内膜炎患者血液凝固性增加、血小板活化与栓塞事件
Clin Cardiol. 2004 Mar;27(3):154-8. doi: 10.1002/clc.4960270312.
7
Peptidoglycan from Staphylococcus aureus induces tissue factor expression and procoagulant activity in human monocytes.来自金黄色葡萄球菌的肽聚糖可诱导人单核细胞中组织因子的表达及促凝血活性。
Infect Immun. 2002 Jun;70(6):3033-9. doi: 10.1128/IAI.70.6.3033-3039.2002.
8
Interleukin-10 regulates the tissue factor activity of monocytes in an in vitro model of bacterial endocarditis.白细胞介素-10在细菌性心内膜炎的体外模型中调节单核细胞的组织因子活性。
Infect Immun. 2001 May;69(5):3197-202. doi: 10.1128/IAI.69.5.3197-3202.2001.
9
Monocytes augment bacterial species- and strain-dependent induction of tissue factor activity in bacterium-infected human vascular endothelial cells.单核细胞增强细菌感染的人血管内皮细胞中组织因子活性的细菌种类和菌株依赖性诱导。
Infect Immun. 2001 May;69(5):2797-807. doi: 10.1128/IAI.69.5.2797-2807.2001.
10
Staphylococcus aureus, Platelets, and the Heart.金黄色葡萄球菌、血小板与心脏
Curr Infect Dis Rep. 2000 Aug;2(4):281-298. doi: 10.1007/s11908-000-0005-0.
本文引用的文献
1
Effects of monocytopenia and anticoagulation in experimental Streptococcus sanguis endocarditis.单核细胞减少症和抗凝在实验性血链球菌心内膜炎中的作用。
Br J Exp Pathol. 1980 Feb;61(1):108-16.
2
Role of granulocytes in the prevention and therapy of experimental Streptococcus sanguis endocarditis in rabbits.粒细胞在兔实验性血链球菌心内膜炎预防和治疗中的作用
Antimicrob Agents Chemother. 1984 Feb;25(2):263-7. doi: 10.1128/AAC.25.2.263.
3
Tissue factor is a major stimulus for vegetation formation in enterococcal endocarditis in rabbits.组织因子是兔肠球菌性心内膜炎中赘生物形成的主要刺激因素。
J Clin Invest. 1984 Jun;73(6):1750-3. doi: 10.1172/JCI111383.
4
5
Effects of tissue-type plasminogen activator (t-PA) on Streptococcus sanguis-infected endocardial vegetations in vitro.组织型纤溶酶原激活剂（t-PA）对血链球菌感染的心内膜赘生物的体外作用。
J Antimicrob Chemother. 1988 May;21(5):609-20. doi: 10.1093/jac/21.5.609.
6
Procoagulant activity of endocardial vegetations and blood monocytes in rabbits with Streptococcus sanguis endocarditis.血链球菌性心内膜炎家兔心内膜赘生物及血液单核细胞的促凝活性
Thromb Haemost. 1989 Nov 24;62(3):1029-33.
7
Cultured normal human hepatocytes do not synthesize lipoprotein-associated coagulation inhibitor: evidence that endothelium is the principal site of its synthesis.培养的正常人肝细胞不合成脂蛋白相关凝血抑制剂：内皮是其合成主要部位的证据。
Proc Natl Acad Sci U S A. 1990 Nov;87(22):8869-73. doi: 10.1073/pnas.87.22.8869.
8
Extrinsic activation of human coagulation factors IX and X on the endothelial surface.人凝血因子IX和X在内皮表面的外源性激活。
Thromb Haemost. 1991 Sep 2;66(3):283-91.
9
The role of leukocytes in the activation of blood coagulation.白细胞在血液凝固激活中的作用。
Semin Hematol. 1992 Jul;29(3):202-12.
10
The tissue factor pathway of blood coagulation.血液凝固的组织因子途径。
Semin Hematol. 1992 Jul;29(3):170-6.
Zotero 插件