Hutchinson R M, Eastham R D
J Clin Pathol. 1977 Apr;30(4):345-9. doi: 10.1136/jcp.30.4.345.
The Westergren erythrocyte sedimentation rate (ESR) and plasma viscosity were compared in 114 patients and their correlations with total and differential plasma protein fractions were analysed. There is a linear correlation between these two screening tests. Higher correlation coefficients were obtained between the plasma viscosity and fibrinogen and alpha and gamma globulins than with the ESR. Albumin affected the two tests in opposite directions. The ESR was falsely increased by a fall in haemoglobulin even within two standard deviations from the mean. Both tests gave an appreciable number of incorrect values--the plasma viscosity in 21 cases and the ESR in 33. The cause for these is discussed. It is concluded that the plasma viscosity is the more sensitive and reliable measure of changes in acute phase protein reactants and more useful for monitoring clinical progress.
对114例患者的魏氏红细胞沉降率（ESR）和血浆粘度进行了比较，并分析了它们与血浆总蛋白和不同蛋白组分的相关性。这两项筛查试验之间存在线性相关性。与ESR相比，血浆粘度与纤维蛋白原、α球蛋白和γ球蛋白之间的相关系数更高。白蛋白对这两项试验的影响方向相反。即使血红蛋白下降幅度在均值的两个标准差范围内，ESR也会出现假性升高。两项试验均出现了相当数量的错误值——21例血浆粘度测量值错误，33例ESR测量值错误。文中对这些错误的原因进行了讨论。得出的结论是，血浆粘度是急性期蛋白反应变化更敏感、更可靠的指标，对监测临床进展更有用。
