Dulloo A G, Miller D S
Can J Physiol Pharmacol. 1984 Feb;62(2):235-40. doi: 10.1139/y84-035.
The effects of sham, bilateral surgical denervation or excision of interscapular brown adipose tissue on body composition and energetic efficiency were studied in young CFLP mice kept at 25 degrees C and fed a laboratory stock diet. A preliminary experiment showed that 15 weeks following surgery, total body fat was increased by 42% in the denervated group and by 72% in the excised group while body protein was unchanged. In another 7-week energy balance experiment, body fat was also significantly higher by 15 and 18% in the denervated and excised group, respectively, but metabolizable energy intake was slightly lower than that of sham controls. Determination of energy expenditure both by the comparative carcass slaughter technique and by measurement of daily oxygen consumption showed that the metabolic rate was reduced in the denervated nd excised groups. The capacity for thermogenesis, as measured by an increase in oxygen consumption following injections of noradrenaline (600 micrograms/kg body weight) was similar in energetic efficiency, and indicates an important role of the sympathetic nervous system in the regulation of animal heat production by brown adipose tissue and in the overall control of thermogenesis.
在25摄氏度环境下饲养并喂食实验室标准饲料的年轻CFLP小鼠中，研究了假手术、双侧手术去神经支配或肩胛间棕色脂肪组织切除对身体组成和能量效率的影响。一项初步实验表明，术后15周，去神经支配组的全身脂肪增加了42%，切除组增加了72%，而身体蛋白质没有变化。在另一项为期7周的能量平衡实验中，去神经支配组和切除组的身体脂肪也分别显著高出15%和18%，但可代谢能量摄入量略低于假手术对照组。通过比较胴体屠宰技术和测量每日耗氧量来测定能量消耗，结果表明去神经支配组和切除组的代谢率降低。通过注射去甲肾上腺素（600微克/千克体重）后耗氧量的增加来测量产热能力，发现两组在能量效率方面相似，这表明交感神经系统在棕色脂肪组织调节动物产热以及在整体产热控制中起着重要作用。
