Duvoisin R C
Can J Neurol Sci. 1984 Feb;11(1 Suppl):151-5. doi: 10.1017/s031716710004631x.
A considerable proportion of patients with Parkinson's disease report having affected relatives. However, anamnestic data obtained from probands on the occurrence of secondary cases among their relatives are of limited value. In considering the possible role of heredity in Parkinson's disease it is necessary to carefully distinguish between the disease and other disorders such as essential tremor and olivopontocerebellar atrophy which may manifest parkinsonian features. Controlled family studies have shown only a very slight excess of secondary cases among index siblings as compared to spouse siblings. The concordance rate for Parkinson's disease among identical twins is extraordinarily low and does not significantly exceed that among fraternal twins or that expected from the prevalence rate among siblings found in the controlled family studies. The available evidence indicates that heredity plays no significant role in the etiology of Parkinson's disease. Consequently the disease must be considered to be acquired.
相当一部分帕金森病患者报告称有亲属患病。然而，从先证者那里获得的关于其亲属中二代病例发生情况的既往数据价值有限。在考虑遗传因素在帕金森病中可能扮演的角色时，有必要仔细区分帕金森病与其他疾病，如可能表现出帕金森病特征的特发性震颤和橄榄脑桥小脑萎缩。对照家族研究表明，与配偶的兄弟姐妹相比，先证者的同胞中二代病例仅略有增加。同卵双胞胎中帕金森病的一致率极低，且并未显著超过异卵双胞胎或对照家族研究中兄弟姐妹患病率所预期的一致率。现有证据表明，遗传因素在帕金森病的病因中不起重要作用。因此，必须认为该疾病是后天获得的。
