Alonso M E, Otero E, D'Regules R, Figueroa H H
Can J Neurol Sci. 1986 Aug;13(3):248-51. doi: 10.1017/s0317167100036362.
A sample of 122 patients with Parkinson's Disease was studied for the purpose of investigating if the frequency of relatives affected with Parkinson in this group was higher than in a control group and to see if the genetic load was more important in some of the subtypes of Parkinson described by Barbeau and Pourcher (1982). In our 122 patients, we found that 1.7% were post-encephalic parkinsonian, 12.3% were symptomatic cases and 86% of the idiopathic variety. There were 16.1% early onset patients in the idiopathic group and among these we found 23.5% with a positive family history of Parkinson in the first-degree relatives. In 6 cases with the tremor onset form of the disease, the family history was positive and 5 patients, 4.7% had familial essential tremor-related Parkinsonism. Our results support Barbeau's hypothesis that Parkinson is a heterogeneous disease in which some subtypes (such as early onset Parkinson) have an important genetic susceptibility component.
为了调查该组帕金森病患者中亲属患帕金森病的频率是否高于对照组，并了解在Barbeau和Pourcher（1982年）描述的某些帕金森病亚型中遗传负荷是否更为重要，对122例帕金森病患者进行了研究。在我们的122例患者中，我们发现1.7%为脑炎后帕金森病患者，12.3%为症状性病例，86%为特发性类型。特发性组中有16.1%的早发患者，在这些患者中，我们发现23.5%的患者一级亲属中有帕金森病的阳性家族史。在6例以震颤起病形式发病的患者中，家族史呈阳性，5例患者（4.7%）患有家族性特发性震颤相关性帕金森病。我们的结果支持Barbeau的假设，即帕金森病是一种异质性疾病，其中一些亚型（如早发性帕金森病）具有重要的遗传易感性成分。
