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甲苯肺部吸收与排泄的实验研究

Experimental study on the pulmonary absorption and excretion of toluene.

作者信息

Hobara T, Kobayashi H, Higashihara E, Kawamoto T, Sakai T

出版信息

Int Arch Occup Environ Health. 1984;53(4):337-44. doi: 10.1007/BF00380673.

DOI:10.1007/BF00380673
PMID:6715058
Abstract

Three exposure levels of toluene were inhaled by dogs for 1 h. Toluene concentrations in expired air, arterial blood and venous blood were repeatedly measured. Absorptions of toluene within one hour of exposure were 25, 56 and 74 mg/kg at 700, 1500 and 2000 ppm respectively (absorption ratio = 27%). The cumulative excretion one hour after exposure was 63% of the absorped material at all three exposure levels. Multiple regression analyses were performed to interconnect the independent variables.

摘要

让狗吸入三种暴露水平的甲苯,持续1小时。对呼出气体、动脉血和静脉血中的甲苯浓度进行反复测量。在700、1500和2000 ppm浓度下,暴露1小时内甲苯的吸收量分别为25、56和74毫克/千克(吸收比率 = 27%)。在所有三种暴露水平下,暴露1小时后的累积排泄量为吸收物质的63%。进行多元回归分析以关联自变量。

相似文献

1
Experimental study on the pulmonary absorption and excretion of toluene.甲苯肺部吸收与排泄的实验研究
Int Arch Occup Environ Health. 1984;53(4):337-44. doi: 10.1007/BF00380673.
2
[Experimental examinations and toxicokinetic analysis of the absorption and excretion of 1,1,1-trichloroethane by the lung].
Sangyo Igaku. 1982 Nov;24(6):599-607. doi: 10.1539/joh1959.24.599.
3
[Uptake, elimination and metabolism of tetrachloroethylene in dogs].[犬体内四氯乙烯的摄取、消除与代谢]
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Coexposure to toluene and p-xylene in man: uptake and elimination.人体同时接触甲苯和对二甲苯:吸收与消除
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Differences following skin or inhalation exposure in the absorption and excretion kinetics of trichloroethylene and toluene.经皮肤或吸入接触后,三氯乙烯和甲苯在吸收及排泄动力学方面的差异。
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6
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Biological monitoring for occupational exposure to toluene.职业性甲苯接触的生物监测
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The effects of ethanol on the kinetics of toluene in man.
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本文引用的文献

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9
Metabolism of trichloroethylene in man. II. Pharmacokinetics of metabolites.三氯乙烯在人体中的代谢。II. 代谢物的药代动力学。
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10
Trichloroethylene exposure. Simulation of uptake, excretion, and metabolism using a mathematical model.三氯乙烯暴露。使用数学模型模拟吸收、排泄和代谢。
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