通过测量肺泡浓度来控制工业中四氯乙烯暴露：使用数学模型的理论方法
Control of industrial exposure to tetrachloroethylene by measuring alveolar concentrations: theoretical approach using a mathematical model.
作者信息
Guberan E, Fernandez J
出版信息
Br J Ind Med. 1974 Apr;31(2):159-67. doi: 10.1136/oem.31.2.159.
Abstract
159-167. The uptake, distribution, and elimination of tetrachloroethylene were studied using a mathematical model, and predicted alveolar concentrations were compared with experimental data. Because of its high fat solubility the solvent accumulated in adipose tissue with a predicted biological half-life of 71·5 hours. The relation between the alveolar concentrations and the level or duration of exposure was discussed. The alveolar concentrations of tetrachloroethylene during and after similar exposure were predicted in subjects who differed in age, body weight, height, and body fat content, both at rest and during physical effort. Predictions were made of the alveolar concentrations following exposures to steady and variable concentrations in ambient air, and following exposures of several weeks of the type occuring in industry. It was concluded that measurement of the postexposure alveolar concentrations could be used to estimate the mean exposure to tetrachloroethylene in most industrial situations.
摘要
159 - 167. 使用数学模型研究了四氯乙烯的摄取、分布和消除情况，并将预测的肺泡浓度与实验数据进行了比较。由于其高脂溶性，该溶剂在脂肪组织中蓄积，预测的生物半衰期为71.5小时。讨论了肺泡浓度与暴露水平或持续时间之间的关系。预测了年龄、体重、身高和体脂含量不同的受试者在休息和体力活动期间及之后，暴露于相似情况下四氯乙烯的肺泡浓度。还预测了在环境空气中暴露于稳定和可变浓度以及在工业中发生的数周暴露类型后肺泡的浓度。得出的结论是，在大多数工业情况下，测量暴露后肺泡浓度可用于估计四氯乙烯的平均暴露量。
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Control of industrial exposure to tetrachloroethylene by measuring alveolar concentrations: theoretical approach using a mathematical model.通过测量肺泡浓度来控制工业中四氯乙烯暴露：使用数学模型的理论方法
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