来自巴布亚新几内亚的美拉尼西亚椭圆形红细胞的膜变形性降低。
Decreased membrane deformability in Melanesian ovalocytes from Papua New Guinea.
作者信息
Saul A, Lamont G, Sawyer W H, Kidson C
出版信息
J Cell Biol. 1984 Apr;98(4):1348-54. doi: 10.1083/jcb.98.4.1348.
Abstract
We examined the ability of Melanesian ovalocytes from Papua New Guinea to be deformed in order to probe the resistance of these cells to invasion by several species of malaria parasite. We found ovalocytes were refractile to drug-induced endocytosis, that they formed abnormal rouleaux, showed reduced deformability when aspirated into 0.6-micron diameter pores in polycarbonate sieves, and failed to crenate when mounted under a glass coverslip. No substantial differences were found between normocytes and ovalocytes in their initial rate of filtration through 4.5-micron pore polycarbonate sieves, their membrane fluidity as measured by the rate of depolarization of fluorescent probes or the rate of extraction of cytoskeletal proteins in low ionic strength buffers. We conclude that the resistance of ovalocytes to undergo localized deformation might be significant in explaining the resistance of these cells to invasion by malarial merozoites.
摘要
我们研究了来自巴布亚新几内亚的美拉尼西亚椭圆形红细胞的变形能力，以探究这些细胞对几种疟原虫入侵的抗性。我们发现椭圆形红细胞对药物诱导的内吞作用具有抗性，它们形成异常的缗钱状，当被吸入聚碳酸酯筛板中直径为0.6微米的孔时显示出变形性降低，并且在置于盖玻片下时不会皱缩。正常红细胞和椭圆形红细胞在通过4.5微米孔径聚碳酸酯筛板的初始过滤速率、通过荧光探针去极化速率测量的膜流动性或在低离子强度缓冲液中细胞骨架蛋白的提取速率方面没有发现实质性差异。我们得出结论，椭圆形红细胞抵抗局部变形的能力可能在解释这些细胞对疟原虫裂殖子入侵的抗性方面具有重要意义。
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