Deutscher S, Rockette H E, Krishnaswami V
J Chronic Dis. 1984;37(5):407-15. doi: 10.1016/0021-9681(84)90108-5.
To help clarify the etiology and pathogenesis of calcific aortic stenosis, we studied retrospectively the relationship existing between that condition and two presumptive risk factors: diabetes and hypercholesterolemia. Fifty-four patients with isolated aortic stenosis, undergoing cardiac catheterization, were compared to patients without aortic stenosis who underwent angiography for unrelated reasons. The effect of diabetes and hypercholesterolemia, singly and in combination, upon the prevalence of aortic stenosis, was tested by various methods, including mathematical model fitting: Both study factors were found to be associated with aortic stenosis; their combined effect upon the prevalence of that disease appeared to be multiplicative. These findings suggest that diabetes and hypercholesterolemia may play a role in the causation of aortic stenosis. Further studies among unselected populations are needed to confirm the existence of the associations uncovered.
为了帮助阐明钙化性主动脉瓣狭窄的病因和发病机制，我们回顾性研究了该病症与两个假定风险因素之间的关系：糖尿病和高胆固醇血症。将54例接受心脏导管检查的单纯性主动脉瓣狭窄患者与因无关原因接受血管造影的无主动脉瓣狭窄患者进行比较。通过包括数学模型拟合在内的各种方法，测试了糖尿病和高胆固醇血症单独及联合对主动脉瓣狭窄患病率的影响：发现这两个研究因素均与主动脉瓣狭窄相关；它们对该疾病患病率的联合作用似乎是相乘的。这些发现表明，糖尿病和高胆固醇血症可能在主动脉瓣狭窄的病因中起作用。需要在未选定的人群中进行进一步研究，以证实所发现的关联的存在。
