Mills J L, Jefferys J L, Stolley P D
J Occup Med. 1984 Apr;26(4):269-72.
This report describes the health effects of occupational exposure during manufacturing processes that utilize synthetic estrogens and progestogens, and demonstrates the usefulness of various laboratory assays in identifying workers who have experienced actual hormone absorption. In late 1978 the health status of exposed and unexposed workers was compared by standardized questionnaire, physical examination, and laboratory studies. A higher proportion of exposed than unexposed men gave histories of breast swelling (p less than .0001), nodules (p = .0003), and nipple discharge (p = .037). Physical examination showed no significant differences between groups. Exposed and unexposed workers showed no clinically significant differences on any routine laboratory studies. Hormone studies revealed significantly lower natural total serum estrogen levels in exposed men and women. Serum norethindrone levels were useful in identifying workers with hormone exposure in their recent past. Hormone exposure continued to cause physiologic disturbances during the period studied despite efforts to control exposure. Measuring blood norethindrone levels may be a valuable way of identifying exposed workers.
本报告描述了在使用合成雌激素和孕激素的制造过程中职业暴露对健康的影响，并证明了各种实验室检测方法在识别实际接触过激素的工人方面的有用性。1978年末，通过标准化问卷、体格检查和实验室研究对暴露组和未暴露组工人的健康状况进行了比较。与未暴露组男性相比，暴露组男性中有更高比例的人有乳房肿胀史（p＜0.0001）、结节史（p = 0.0003）和乳头溢液史（p = 0.037）。体格检查显示两组之间无显著差异。在任何常规实验室检查中，暴露组和未暴露组工人均未显示出临床显著差异。激素研究显示，暴露组男性和女性的天然总血清雌激素水平显著较低。血清炔诺酮水平有助于识别近期接触过激素的工人。尽管采取了控制暴露的措施，但在研究期间，激素暴露仍继续导致生理紊乱。测量血液中的炔诺酮水平可能是识别暴露工人的一种有价值的方法。
