白血病中的免疫机制：Ia抗原的作用
Immune mechanisms in leukemia role of the Ia antigens.
作者信息
Lukasewycz O A, Frelinger J A
出版信息
J Exp Med. 1977 Apr 1;145(4):1077-81. doi: 10.1084/jem.145.4.1077.
Abstract
We have shown that the selective removal of cells possessing Ia determinants coded by the I-A, I-B, and I-J regions of the H-2 gene complex completely abrogates the protective capacity of nylon-wool-purified T lymphocytes against leukemic challenge. This suggests that the Ia antigen bearing T cells play an important role in tumor immunity.
摘要
我们已经证明，选择性去除具有由H-2基因复合体的I-A、I-B和I-J区域编码的Ia决定簇的细胞，会完全消除尼龙毛纯化的T淋巴细胞对白血病攻击的保护能力。这表明携带Ia抗原的T细胞在肿瘤免疫中起重要作用。
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Immune mechanisms in leukemia role of the Ia antigens.白血病中的免疫机制：Ia抗原的作用
J Exp Med. 1977 Apr 1;145(4):1077-81. doi: 10.1084/jem.145.4.1077.
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本文引用的文献
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Immunization of C58 mice to line Ib leukemia.将C58小鼠免疫至I b型白血病。
Cancer Res. 1969 Dec;29(12):2157-62.
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A rapid method for the isolation of functional thymus-derived murine lymphocytes.一种分离功能性胸腺来源的小鼠淋巴细胞的快速方法。
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Evidence for the expression of Ia (H-2-associated) antigens on thymus-derived lymphocytes.胸腺来源淋巴细胞上Ia（与H-2相关）抗原表达的证据。
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4
New lymphocyte antigen system (Lna) controlled by the Ir region of the mouse H-2 complex.由小鼠H-2复合体的Ir区域控制的新淋巴细胞抗原系统（Lna）。
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Immune mechanisms in leukemia: suppression of cellular immunity by starvation.白血病中的免疫机制：饥饿对细胞免疫的抑制。
J Natl Cancer Inst. 1975 Oct;55(4):935-9. doi: 10.1093/jnci/55.4.935.
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Immune mechanisms in leukemia: suppression of cellular immunity by drugs and x-irradiation.白血病中的免疫机制：药物和X射线对细胞免疫的抑制作用。
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7
Ia alloantigen(s) detected on thymocytes by use of a fluorescence-activated cell sorter.通过使用荧光激活细胞分选仪在胸腺细胞上检测到Ia同种抗原。
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8
Functional subclasses of T-lymphocytes bearing different Ly antigens. I. The generation of functionally distinct T-cell subclasses is a differentiative process independent of antigen.带有不同Ly抗原的T淋巴细胞功能亚类。I. 功能不同的T细胞亚类的产生是一个独立于抗原的分化过程。
J Exp Med. 1975 Jun 1;141(6):1376-89. doi: 10.1084/jem.141.6.1376.
9
Immune mechanisms in leukemia: evaluation of immunocompetent cell populations.白血病中的免疫机制：免疫活性细胞群体评估
J Immunol. 1975 May;114(5):1491-6.
10
A new I subregion (I-J) marked by a locus (Ia-4) controlling surface determinants on suppressor T lymphocytes.一个新的I亚区（I-J），由一个控制抑制性T淋巴细胞表面决定簇的基因座（Ia-4）标记。
J Exp Med. 1976 Sep 1;144(3):699-712. doi: 10.1084/jem.144.3.699.
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