Habenicht A J, Goerig M, Schettler G
Klin Wochenschr. 1984 Mar 15;62(6):241-53. doi: 10.1007/BF01721885.
Early lesions of arteriosclerosis are characterized by proliferating smooth muscle cells, macrophages,and foam cells. In addition, large amounts of connective tissue components and cholesterol esters are found. These changes are primarily located in the intima of the arterial wall. The initial mechanisms responsible for lesion formation are largely unknown. In recent years progress has been made particularly in fields of research related to the biochemistry of arterial wall cells in tissue culture. The findings obtained allow us to deepen our knowledge of the pathophysiology of arteriosclerosis. Of special interest are mechanisms involved in the maintenance of the thromboresistant endothelium, the factors triggering proliferation of intimal smooth muscle cells, and the transformation of macrophages to foam cells.
动脉粥样硬化的早期病变特征为平滑肌细胞、巨噬细胞和泡沫细胞的增殖。此外，还发现大量结缔组织成分和胆固醇酯。这些变化主要位于动脉壁的内膜。病变形成的初始机制在很大程度上尚不清楚。近年来，特别是在组织培养中动脉壁细胞生物化学相关的研究领域取得了进展。所获得的研究结果使我们能够加深对动脉粥样硬化病理生理学的认识。特别值得关注的是与维持抗血栓形成内皮相关的机制、触发内膜平滑肌细胞增殖的因素以及巨噬细胞向泡沫细胞的转化。
