万古霉素：一种用于强效抗生素的快速高效液相色谱测定法。
Vancomycin: a rapid HPLC assay for a potent antibiotic.
作者信息
Hoagland R J, Sherwin J E, Phillips J M
出版信息
J Anal Toxicol. 1984 Mar-Apr;8(2):75-7. doi: 10.1093/jat/8.2.75.
PMID:6716979
Abstract
Vancomycin 'Vancocin HCl' is a potent antimicrobial used most frequently in the treatment of gram positive septicemias. Ototoxicity has occurred at serum levels of 80 micrograms/mL. A rapid, sensitive assay for vancomycin that utilizes high-pressure liquid chromatography with ultraviolet detection, and requires only 100 microL of serum, is presented. The method shows excellent linearity and precision throughout the therapeutic and toxic range.
摘要
万古霉素“盐酸万古霉素”是一种强效抗菌药物，最常用于治疗革兰氏阳性菌败血症。血清浓度达到80微克/毫升时会出现耳毒性。本文介绍了一种利用高压液相色谱法和紫外线检测技术对万古霉素进行快速、灵敏检测的方法，该方法仅需100微升血清。该方法在治疗和中毒范围内均显示出优异的线性和精密度。
相似文献
1
Vancomycin: a rapid HPLC assay for a potent antibiotic.万古霉素：一种用于强效抗生素的快速高效液相色谱测定法。
J Anal Toxicol. 1984 Mar-Apr;8(2):75-7. doi: 10.1093/jat/8.2.75.
2
A Rapid and Simple HPLC Method for Therapeutic Monitoring of Vancomycin.一种用于万古霉素治疗监测的快速简便的高效液相色谱法。
J Chromatogr Sci. 2018 Feb 1;56(2):115-121. doi: 10.1093/chromsci/bmx089.
3
Quantitation of vancomycin and its crystalline degradation product (CDP-1) in human serum by high performance liquid chromatography.采用高效液相色谱法对人血清中万古霉素及其结晶降解产物（CDP-1）进行定量分析。
J Pharm Biomed Anal. 1998 Apr;16(8):1281-7. doi: 10.1016/s0731-7085(97)00140-4.
4
Successful management of discovered pH dependence in vancomycin recovery studies: novel HPLC method for microdialysis and plasma samples.万古霉素回收率研究中已发现的pH依赖性的成功管理：用于微透析和血浆样品的新型高效液相色谱法
Biomed Chromatogr. 2005 Apr;19(3):237-44. doi: 10.1002/bmc.446.
5
An automated analyzer for vancomycin in plasma samples by column-switching high-performance liquid chromatography with UV detection.一种采用柱切换高效液相色谱法并结合紫外检测的血浆样本中万古霉素自动分析仪。
Biomed Chromatogr. 2004 Nov;18(9):735-8. doi: 10.1002/bmc.386.
6
[HPLC, RIA, FPIA. Evaluation of 3 methods for the assay of vancomycin].[高效液相色谱法、放射免疫分析法、荧光偏振免疫分析法。万古霉素测定3种方法的评估]
Pathol Biol (Paris). 1985 Jun;33(5 Pt 2):511-6.
7
High performance liquid chromatographic assay of vancomycin in serum.血清中万古霉素的高效液相色谱测定法
Ther Drug Monit. 1979;1(1):75-83. doi: 10.1097/00007691-197901000-00008.
8
Ototoxicity of vancomycin and analogues.万古霉素及其类似物的耳毒性。
Otolaryngol Clin North Am. 1993 Oct;26(5):821-8.
9
Determination of vancomycin in human plasma using high-performance liquid chromatography with fluorescence detection.采用高效液相色谱-荧光检测法测定人血浆中的万古霉素。
Anal Bioanal Chem. 2009 Sep;395(2):527-32. doi: 10.1007/s00216-009-2948-9. Epub 2009 Aug 5.
10
Determination of vancomycin in human serum by high-pressure liquid chromatography.采用高压液相色谱法测定人血清中的万古霉素。
Antimicrob Agents Chemother. 1985 Apr;27(4):503-7. doi: 10.1128/AAC.27.4.503.
引用本文的文献
1
Development and validation of an HPLC method for the determination of vancomycin in human plasma and its comparison with an immunoassay (PETINIA).一种用于测定人血浆中万古霉素的高效液相色谱法的建立与验证及其与免疫分析法（PETINIA）的比较
Springerplus. 2016 Feb 18;5:124. doi: 10.1186/s40064-016-1778-4. eCollection 2016.
2
Clinical pharmacokinetics of vancomycin.万古霉素的临床药代动力学
Clin Pharmacokinet. 1986 Jul-Aug;11(4):257-82. doi: 10.2165/00003088-198611040-00001.
Zotero 插件