Nencini P, Ahmed A M, Amiconi G, Elmi A S
Pharmacology. 1984;28(3):150-4. doi: 10.1159/000137956.
Khat chewing has been found to induce, like amphetamines, psychostimulation and increase in sympathetic tone. The possibility that tolerance develops to these effects has been studied by comparing the influence of the chewing of a standard dose of khat on some physiological parameters in chronic consumers and naive subjects. Systolic blood pressure appears to rise in both groups, but the increase in diastolic pressure was more marked in naive subjects and inversely related to the reduction of pulse rate. The increases of respiratory rate and body temperature were also higher in naive subjects. In both groups, all these effects disappeared after 18 h. These results are consistent with an amphetamine-like mechanism of action and suggest that tolerance develops to the sympathetic effects of khat.
已发现咀嚼巧茶与安非他命一样，会引起精神兴奋并增强交感神经张力。通过比较标准剂量巧茶咀嚼对长期使用者和未接触者某些生理参数的影响，研究了对这些效应产生耐受性的可能性。两组受试者的收缩压似乎都会升高，但舒张压的升高在未接触者中更为明显，且与脉搏率的降低呈负相关。未接触者的呼吸频率和体温升高也更高。在两组中，所有这些效应在18小时后均消失。这些结果与类似安非他命的作用机制一致，并表明对巧茶的交感神经效应会产生耐受性。
