Hodgkiss J P
Q J Exp Physiol. 1984 Jan;69(1):161-70. doi: 10.1113/expphysiol.1984.sp002777.
Peristalsis in the chicken caecum was investigated by recording the responses of isolated segments of the caecum to either fluid distension using a modified Trendelenburg apparatus or by monitoring circular muscle activity following localized radial distension of adjacent areas. Raising the intraluminal pressure did not initiate peristalsis except in the presence of tetrodotoxin, local anaesthetics and high concentrations of phentolamine. The effect of these drugs was reversible. Localized distension generally produced either a small relaxation of the circular muscle or no response at all on both sides of the site of distension. After exposure to tetrodotoxin one, or more (usually several), rhythmic propogating contractions were initiated at the point of distension. These results suggest that intrinsic inhibitory neurones are present in the caecum and may be triggered by distention. The possible role of these inhibitory neurones in the emptying and filling of the caecae is considered.
通过使用改良的特伦德伦伯卧位装置记录盲肠分离段对液体扩张的反应，或通过监测相邻区域局部径向扩张后的环肌活动，对鸡盲肠的蠕动进行了研究。升高腔内压力不会引发蠕动，除非存在河豚毒素、局部麻醉剂和高浓度的酚妥拉明。这些药物的作用是可逆的。局部扩张通常会使扩张部位两侧的环肌出现轻微松弛或根本没有反应。暴露于河豚毒素后，在扩张点会引发一次或多次（通常是几次）有节律的传播性收缩。这些结果表明，盲肠中存在内在抑制性神经元，可能由扩张触发。考虑了这些抑制性神经元在盲肠排空和充盈中的可能作用。
