Farr M, Wainwright A, Salmon M, Hollywell C A, Bacon P A
Rheumatol Int. 1984;4(1):13-7. doi: 10.1007/BF00683878.
In a study of synovial fluid from 110 patients with various forms of arthritis, platelets were identified in the synovial fluid of all the 50 rheumatoids, in 18 out of the 25 (72%) with osteoarthritis and in all 35 of those with other forms of inflammatory osteoarthrosis. Identification of platelets by light microscopy was confirmed by electron microscopy. Platelet counts were significantly higher in rheumatoid fluid (mean 14 988/mm3; range 1000-65 000/mm3) compared with fluid from patients with osteoarthrosis (mean 1 592/Mm3; 0-10 000/mm3). In addition, significantly higher platelet counts were found in the synovial fluid (SF) of inflamed joints. There was a positive correlation between the SF platelet count and the total white cell count, polymorph count, hydrogen ion concentration, knee score, acid phosphatase and 5-nucleotidase activity and a negative correlation with the glucose level. All these factors indicate joint activity. Finally, platelet numbers correlated with SF levels of immunoglobulin M, and seropositive patients had significantly higher platelet counts in the SF compared with seronegative patients. Rheumatoid patients with thrombocytosis also had higher SF platelet counts. The close relationship of the SF platelet count to other indices of inflammation supports the concept that platelets may directly contribute to synovial inflammation by a variety of pathways.
在一项对110例患有各种关节炎的患者的滑液研究中，在所有50例类风湿关节炎患者的滑液中均发现了血小板，25例骨关节炎患者中有18例（72%）的滑液中发现了血小板，在所有35例其他形式的炎性骨关节炎患者的滑液中也发现了血小板。通过光学显微镜鉴定血小板得到了电子显微镜的证实。与骨关节炎患者的滑液（平均1592/mm³；范围0 - 10000/mm³）相比，类风湿关节炎患者滑液中的血小板计数显著更高（平均14988/mm³；范围1000 - 65000/mm³）。此外，在发炎关节的滑液中发现血小板计数显著更高。滑液血小板计数与总白细胞计数、多形核白细胞计数、氢离子浓度、膝关节评分、酸性磷酸酶和5 - 核苷酸酶活性呈正相关，与葡萄糖水平呈负相关。所有这些因素都表明关节处于活动状态。最后，血小板数量与滑液中免疫球蛋白M水平相关，血清阳性患者滑液中的血小板计数显著高于血清阴性患者。血小板增多的类风湿关节炎患者滑液中的血小板计数也更高。滑液血小板计数与其他炎症指标的密切关系支持了血小板可能通过多种途径直接导致滑膜炎症的观点。
