Vasa-Thomas K A, Ambrose K R, Bellomy B B, Coggin J H
J Natl Cancer Inst. 1977 May;58(5):1287-93. doi: 10.1093/jnci/58.5.1287.
Tumor resistance could be induced against the transplantation of cell lines derived from spontaneous lymphomas that occurred in the third of three lymphoma epizootics in a hamster colony. Immunization of normal hamsters with irradiated lymphoma cells promoted resistance to homologous lymphoma challenge and prevented the development of spontaneous lymphomas when immunized hamsters were exposed to the contaminated colony. This immunity could be transferred in an adoptive transfer assay. Resistance to direct challenge was not extended to simian virus 40(SV40)-induced sarcomas carrying SV40 tumor-specific transplantation antigen nor to herpesvirus-induced carcinoma cells, indicating specificity. The nature of the antigen(s) involved was discussed.
在一个仓鼠群体中发生的三次淋巴瘤流行中的第三次出现的自发性淋巴瘤所衍生的细胞系移植，可诱导肿瘤抗性。用经辐照的淋巴瘤细胞对正常仓鼠进行免疫，可促进对同源淋巴瘤攻击的抗性，并在将免疫的仓鼠暴露于受污染的群体时预防自发性淋巴瘤的发生。这种免疫力可在过继转移试验中转移。对直接攻击的抗性并未扩展到携带猿猴病毒40（SV40）肿瘤特异性移植抗原的SV40诱导的肉瘤，也未扩展到疱疹病毒诱导的癌细胞，表明具有特异性。文中讨论了所涉及抗原的性质。
