Jamal K, Cooney T P, Fleetham J A, Thurlbeck W M
Am Rev Respir Dis. 1984 May;129(5):719-22. doi: 10.1164/arrd.1984.129.5.719.
We have assessed bronchial mucous gland size in a group of 26 patients with severe chronic air-flow obstruction and hypoxemia from the NIH Nocturnal Oxygen Therapy Trial. These patients had their sputum volume assessed at least 4 times when free from exacerbations. Mucous gland size was assessed by the gland/wall ratio (Reid Index), by absolute gland area, and by the volume proportion of glands. The volume of sputum produced was significantly related to the volume proportion of mucous glands (Rho = 0.53, p less than 0.01) and to the absolute gland area (Rho = 0.49, p less than 0.05), but not to the Reid Index, (Rho = 0.35, p greater than 0.05). Volume proportion of glands can be easily and quickly measured using a computer-assisted digitizer, and it is the method of choice for measuring mucous gland size in this series. Neither the Reid Index nor the volume proportion of glands was related to the forced expiratory volume in one second (FEV1), and the measurements were not significantly related to each other. The amount of sputum produced was not related significantly to the FEV1 (Rho = 0.26, p greater than 0.05).
我们评估了美国国立卫生研究院夜间氧疗试验中一组26例患有严重慢性气流阻塞和低氧血症患者的支气管黏液腺大小。这些患者在病情未加重时，其痰液量至少被评估了4次。黏液腺大小通过腺体/管壁比率（里德指数）、腺体绝对面积和腺体体积比例来评估。所产生痰液的体积与黏液腺的体积比例显著相关（相关系数Rho = 0.53，p小于0.01），与腺体绝对面积也显著相关（Rho = 0.49，p小于0.05），但与里德指数无关（Rho = 0.35，p大于0.05）。腺体体积比例可以使用计算机辅助数字化仪轻松快速地测量，并且它是本系列中测量黏液腺大小的首选方法。里德指数和腺体体积比例均与一秒用力呼气量（FEV1）无关，且这些测量值之间也无显著相关性。所产生的痰液量与FEV1无显著相关性（Rho = 0.26，p大于0.05）。
