Oberholzer M, Dalquen P, Wyss M, Rohr H P
Thorax. 1978 Dec;33(6):779-84. doi: 10.1136/thx.33.6.779.
We studied at necropsy the bronchi of 49 subjects whose lung function has been measured during life. In each case the glands were examined in three bronchi by measuring the gland/wall ratio (Reid-Index) and by point-counting. The results of the two methods were compared: the data of the gland/wall ratio were normally distributed while those of the volume density established by point-counting were not. Gland/wall ratio and volume density of glands correlated moderately (RSp = 0.524). The function between them was not linear, in contrast with that between gland/wall ratio and gland thickness. The stereological background of these functions is discussed. In 34 subjects without restrictive lung disease FEV1 correlated inversely with the volume density of glands (RSp = -0.396), but not with the gland/wall ratio (Reid-Index)(RSp = -0.243). This discrepancy probably results from the different distribution of the data obtained by the two methods and from the non-linear function between them. These findings indicate that the gland/wall ratio (Reid-Index) is less applicable to clinicopathological correlations than the volume density of glands established by point-counting.
我们在尸检时研究了49名生前已测量过肺功能的受试者的支气管。在每种情况下，通过测量腺体/管壁比值（里德指数）和点计数法对三个支气管中的腺体进行检查。比较了两种方法的结果：腺体/管壁比值的数据呈正态分布，而通过点计数法确定的体积密度数据则不然。腺体/管壁比值与腺体体积密度呈中度相关（RSp = 0.524）。与腺体/管壁比值和腺体厚度之间的关系不同，它们之间的函数不是线性的。讨论了这些函数的体视学背景。在34名无限制性肺病的受试者中，FEV1与腺体体积密度呈负相关（RSp = -0.396），但与腺体/管壁比值（里德指数）无相关性（RSp = -0.243）。这种差异可能是由于两种方法获得的数据分布不同以及它们之间的非线性函数所致。这些发现表明，与通过点计数法确定的腺体体积密度相比，腺体/管壁比值（里德指数）在临床病理相关性方面的适用性较差。
