Meltzer H Y, Kolakowska T, Fang V S, Fogg L, Robertson A, Lewine R, Strahilevitz M, Busch D
Arch Gen Psychiatry. 1984 May;41(5):512-9. doi: 10.1001/archpsyc.1984.01790160098013.
The responses of serum prolactin (PRL) and growth hormone (GH) to the dopamine agonist apomorphine hydrochloride (0.75 mg subcutaneously) were studied in a large group of unmedicated hospitalized patients with functional psychoses. There were no differences in the GH response in various diagnostic groups. The PRL response was greater in patients with affective disorders. The GH response was inversely related to total duration of illness in the entire sample of patients, but this correlation was independent of age effect only in the group of patients with major depression. In schizophrenics, the effect of the two factors, age and duration of the illness, could not be separated. The apomorphine-induced GH response was significantly correlated with psychosis ratings and negative symptom scale scores. The apomorphine-induced PRL suppression correlated significantly with various measures of depression across diagnostic groups.
在一大组未接受药物治疗的住院功能性精神病患者中，研究了血清催乳素（PRL）和生长激素（GH）对多巴胺激动剂盐酸阿扑吗啡（皮下注射0.75毫克）的反应。不同诊断组的GH反应没有差异。情感障碍患者的PRL反应更大。在整个患者样本中，GH反应与疾病总病程呈负相关，但这种相关性仅在重度抑郁症患者组中独立于年龄效应。在精神分裂症患者中，年龄和病程这两个因素的影响无法区分。阿扑吗啡诱导的GH反应与精神病评定和阴性症状量表评分显著相关。阿扑吗啡诱导的PRL抑制与各诊断组的各种抑郁指标显著相关。
