Zimmer R, Teelken A W, Trieling W B, Weber W, Weihmayr T, Lauter H
Arch Neurol. 1984 Jun;41(6):602-4. doi: 10.1001/archneur.1984.04210080010005.
The investigation of enzyme and neurotransmitter levels and/or their metabolites in the CSF of patients with senile dementia of Alzheimer's type (SDAT) could become a promising approach for a clinical research and diagnostic procedure. To learn more about the metabolic reflections of central metabolism in the CSF of patients with SDAT, we measured CSF levels of gamma-aminobutyric acid (GABA) and homovanillic acid (HVA), the dopamine metabolite. In 16 female patients with SDAT and in eight matched control patients, CSF GABA levels were measured by ion exchange with fluorimetric detection, and HVA levels were measured fluorimetrically. The GABA content of the CSF was significantly reduced in patients with SDAT, whereas the HVA level was unchanged.
对阿尔茨海默型老年痴呆症（SDAT）患者脑脊液中的酶和神经递质水平及/或其代谢产物进行研究，可能会成为临床研究和诊断程序的一种有前景的方法。为了更深入了解SDAT患者脑脊液中中枢代谢的代谢反映，我们测量了脑脊液中γ-氨基丁酸（GABA）和多巴胺代谢产物高香草酸（HVA）的水平。对16名女性SDAT患者和8名匹配的对照患者，采用离子交换荧光检测法测量脑脊液GABA水平，并用荧光法测量HVA水平。SDAT患者脑脊液中的GABA含量显著降低，而HVA水平未变。
