Chambers W A, Littlewood D G, Edstrom H H, Scott D B
Br J Anaesth. 1982 Jan;54(1):75-80. doi: 10.1093/bja/54.1.75.
A double-blind study was carried out using hyperbaric solutions of bupivacaine to compare the effects of varying the concentration of bupivacaine and the volume of solution administered intrathecally. Fifty-seven patients were studied. Ten patients received each volume of each concentration: 0.5% bupivacaine in 8% dextrose, 2 ml, 3 ml or 4 ml and 0.75% bupivacaine in 8% dextrose, 1.3 ml or 2 ml. A further seven patients received 3 ml of the 0.75% solution. Both solutions consistently produced good nerve blockade. With the 0.5% solution, increases in the volume administered had no effect on the spread of sensory loss, whereas with the 0.75% solution, increasing the volume administered resulted in a significantly greater cephalad spread. The use of 3 ml of this solution was abandoned after seven patients had received it because of the excessive spread. With both solutions, increasing the volume produced a longer duration of action. The use of a 0.75% solution of hyperbaric bupivacaine for spinal anaesthesia did not appear to confer any advantage over the 0.5% solution.
采用布比卡因高压溶液进行了一项双盲研究，以比较改变布比卡因浓度和鞘内给药溶液体积的效果。共研究了57例患者。每种浓度的每种体积分别有10例患者接受：8%葡萄糖溶液中的0.5%布比卡因，2ml、3ml或4ml，以及8%葡萄糖溶液中的0.75%布比卡因，1.3ml或2ml。另外7例患者接受3ml的0.75%溶液。两种溶液均能持续产生良好的神经阻滞。使用0.5%溶液时，给药体积增加对感觉丧失的范围没有影响，而使用0.75%溶液时，给药体积增加导致头端扩散明显更大。7例患者接受3ml该溶液后，因其扩散过度而放弃使用。两种溶液增加体积均能延长作用持续时间。高压布比卡因0.75%溶液用于脊髓麻醉似乎并不比0.5%溶液有任何优势。
