精子穿透的机械假说。
Mechanical hypothesis of sperm penetration.
作者信息
Green D P, Purves R D
出版信息
Biophys J. 1984 Apr;45(4):659-62. doi: 10.1016/S0006-3495(84)84207-1.
Abstract
Sperm have generally been supposed to penetrate the zona pellucida surrounding the mammalian egg with the aid of a protease, acrosin. Difficulties associated with this view are discussed and an alternative, mechanical hypothesis introduced. The calculated force exerted by individual sperm is too small to permit the rupture of any but the weakest of secondary chemical bonds. Mechanical progress through the zona must rely on stress relaxation in a viscoelastic medium. The known properties of the zona appear to be consistent with such a mechanism of penetration.
摘要
一般认为，精子是借助一种蛋白酶——顶体素，穿透围绕哺乳动物卵子的透明带的。本文讨论了与这一观点相关的难点，并提出了另一种机械假说。计算表明，单个精子施加的力太小，除了最弱的二级化学键外，无法使其他化学键断裂。精子在透明带中的推进必须依靠粘弹性介质中的应力松弛。透明带的已知特性似乎与这种穿透机制相一致。
相似文献
1
Mechanical hypothesis of sperm penetration.
Biophys J. 1984 Apr;45(4):659-62. doi: 10.1016/S0006-3495(84)84207-1.
2
PH-20 but not acrosin is involved in sperm penetration of the macaque zona pellucida.
Mol Reprod Dev. 1999 Jul;53(3):350-62. doi: 10.1002/(SICI)1098-2795(199907)53:3<350::AID-MRD11>3.0.CO;2-9.
3
Sperm penetration through cumulus mass and zona pellucida.
Int J Dev Biol. 2008;52(5-6):677-82. doi: 10.1387/ijdb.072528ek.
4
Mechanics of sperm-egg interaction at the zona pellucida.
Biophys J. 1988 Oct;54(4):643-54. doi: 10.1016/S0006-3495(88)83000-5.
5
Acrosin is essential for sperm penetration through the zona pellucida in hamsters.
Proc Natl Acad Sci U S A. 2020 Feb 4;117(5):2513-2518. doi: 10.1073/pnas.1917595117. Epub 2020 Jan 21.
6
Normal penetration of rabbit spermatozoa through a trypsin- and acrosin-resistant zona pellucida.
J Reprod Fertil. 1978 Nov;54(2):385-92. doi: 10.1530/jrf.0.0540385.
7
Sperm from mice carrying a targeted mutation of the acrosin gene can penetrate the oocyte zona pellucida and effect fertilization.
J Biol Chem. 1994 Dec 16;269(50):31845-9.
8
Mammalian sperm cannot penetrate the zona pellucida solely by force.
Exp Cell Res. 1987 Mar;169(1):31-8. doi: 10.1016/0014-4827(87)90221-7.
9
The extracellular protein coat of the inner acrosomal membrane is involved in zona pellucida binding and penetration during fertilization: characterization of its most prominent polypeptide (IAM38).
Dev Biol. 2006 Feb 1;290(1):32-43. doi: 10.1016/j.ydbio.2005.11.003. Epub 2005 Dec 28.
10
Penetration of the zona-free or intact eggs by foreign spermatozoa and the fertilization of deer mouse eggs in vitro.
J Exp Zool. 1978 Feb;203(2):277-85. doi: 10.1002/jez.1402030210.
引用本文的文献
1
Mechanical tuning of mammalian sperm behaviour by hyperactivation, rheology and substrate adhesion: a numerical exploration.
J R Soc Interface. 2016 Nov;13(124). doi: 10.1098/rsif.2016.0633.
2
Transitional states of acrosomal exocytosis and proteolytic processing of the acrosomal matrix in guinea pig sperm.
Mol Reprod Dev. 2011 Dec;78(12):930-41. doi: 10.1002/mrd.21387. Epub 2011 Sep 14.
3
Sperm proteasomes degrade sperm receptor on the egg zona pellucida during mammalian fertilization.
PLoS One. 2011 Feb 23;6(2):e17256. doi: 10.1371/journal.pone.0017256.
4
Mechanics of sperm-egg interaction at the zona pellucida.
Biophys J. 1988 Oct;54(4):643-54. doi: 10.1016/S0006-3495(88)83000-5.
本文引用的文献
1
Surface properties of the zona pellucida.
J Exp Zool. 1980 Jul;213(1):1-8. doi: 10.1002/jez.1402130102.
2
Structure and function of the zona pellucida: identification and characterization of the proteins of the mouse oocyte's zona pellucida.
Dev Biol. 1980 Apr;76(1):185-202. doi: 10.1016/0012-1606(80)90371-1.
3
Isolation, physicochemical properties, and macromolecular composition of zona pellucida from porcine oocytes.
Biochemistry. 1980 Jan 22;19(2):356-65. doi: 10.1021/bi00543a017.
4
Twin-beam laser velocimeter for the investigation of spermatozoon motility.
Biophys J. 1983 Jan;41(1):13-21. doi: 10.1016/S0006-3495(83)84400-2.
5
Ultrastructural changes in the sperm head during fertilization in the rabbit.
Am J Anat. 1968 Sep;123(2):329-58. doi: 10.1002/aja.1001230207.
6
The movement of golden hamster spermatozoa before and after capacitation.
J Reprod Fertil. 1970 Oct;23(1):193-6. doi: 10.1530/jrf.0.0230193.
7
Energy conversion in bull sperm flagella.
J Gen Physiol. 1969 Dec;54(6):782-805. doi: 10.1085/jgp.54.6.782.
8
Fertilization of guinea pig eggs in vitro.
Anat Rec. 1972 Sep;174(1):9-19. doi: 10.1002/ar.1091740103.
9
Permeability of the zona pellucida to protein tracers.
Biol Reprod. 1972 Oct;7(2):288-96. doi: 10.1093/biolreprod/7.2.288.
10
Comparative solubility properties of the zonae pellucidae of unfertilized and fertilized mouse ova.
Biol Reprod. 1974 Dec;11(5):558-65. doi: 10.1095/biolreprod11.5.558.
Zotero 插件