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在大鼠中证明亚硝酸钠挥发性致突变性和致癌性的模型系统。

Model systems demonstrating the volatile mutagenicity and carcinogenicity of sodium nitrite in rats.

作者信息

Macdonald I A, Mader J A, Rao B G, Malatjalian D A

出版信息

Experientia. 1984 Jun 15;40(6):554-7. doi: 10.1007/BF01982327.

DOI:10.1007/BF01982327
PMID:6723926
Abstract

Volatile mutagens derived from sodium nitrite buffered at various pH values or in the presence of human feces were detected using Ames Salmonella tester strain TA 1535 on petrie plates inverted over samples. Volatile mutagenicity increased as the pH decreased and was primarily a function of the nitrous acid produced from sodium nitrite and hydrogen ions. Sodium nitrite administered intracecally to 3 Wistar rats through surgically implanted cannula caused tumors (fibrosarcoma: 1/3 and squamous cell, 2/3). The possible role of nitrite-derived mutagens in GI cancer is discussed.

摘要

使用Ames沙门氏菌测试菌株TA 1535，在倒置在样品上方的皮氏培养皿上，检测在不同pH值缓冲的亚硝酸钠或存在人类粪便的情况下产生的挥发性诱变剂。随着pH值降低，挥发性诱变性增加，这主要是由亚硝酸钠和氢离子产生的亚硝酸的作用。通过手术植入的套管向3只Wistar大鼠的盲肠内注射亚硝酸钠会导致肿瘤（纤维肉瘤：1/3，鳞状细胞癌：2/3）。讨论了亚硝酸盐衍生的诱变剂在胃肠道癌症中的可能作用。

相似文献

1
Model systems demonstrating the volatile mutagenicity and carcinogenicity of sodium nitrite in rats.在大鼠中证明亚硝酸钠挥发性致突变性和致癌性的模型系统。
Experientia. 1984 Jun 15;40(6):554-7. doi: 10.1007/BF01982327.
2
Nitrite-induced volatile mutagens from normal human feces.亚硝酸盐诱导的正常人粪便挥发性诱变剂。
Cancer. 1981 Mar 1;47(5):889-94. doi: 10.1002/1097-0142(19810301)47:5<889::aid-cncr2820470513>3.0.co;2-r.
3
Nitrite-induced volatile fecal mutagens: some preliminary studies.亚硝酸盐诱导的挥发性粪便诱变剂：一些初步研究。
Cancer. 1982 Apr 1;49(7):1405-8. doi: 10.1002/1097-0142(19820401)49:7<1405::aid-cncr2820490716>3.0.co;2-2.
4
Mutagens formed from butylated hydroxyanisole treated with nitrite under acidic conditions.
Mutat Res. 1987 Feb;176(2):179-84. doi: 10.1016/0027-5107(87)90048-0.
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Carcinogenicity of triethanolamine in mice and its mutagenicity after reaction with sodium nitrite in bacteria.三乙醇胺对小鼠的致癌性及其在细菌中与亚硝酸钠反应后的致突变性。
Cancer Res. 1978 Nov;38(11 Pt 1):3918-21.
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Desmutagenic actions of ascorbic acid and cysteine on a new pyrrole mutagen formed by the reaction between food additives; sorbic acid and sodium nitrite.抗坏血酸和半胱氨酸对食品添加剂山梨酸和亚硝酸钠反应形成的一种新型吡咯诱变剂的去诱变作用。
Biochem Biophys Res Commun. 1980 Jul 31;95(2):835-41. doi: 10.1016/0006-291x(80)90863-3.
7
Toxicology and carcinogenesis studies of sodium nitrite (CAS NO. 7632-00-0) in F344/N rats and B6C3F1 mice (drinking water studies).亚硝酸钠（CAS编号：7632-00-0）在F344/N大鼠和B6C3F1小鼠中的毒理学和致癌性研究（饮用水研究）
Natl Toxicol Program Tech Rep Ser. 2001 May;495:7-273.
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[Mutagenicity of alkylnitrites in the Salmonella test].
Boll Soc Ital Biol Sper. 1980 Apr 30;56(8):816-20.
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[Mutagenic activity of basfungin in its combined action with sodium nitrite].[巴斯芬净与亚硝酸钠联合作用的致突变活性]
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本文引用的文献

1
Nitrite-induced volatile mutagens from normal human feces.亚硝酸盐诱导的正常人粪便挥发性诱变剂。
Cancer. 1981 Mar 1;47(5):889-94. doi: 10.1002/1097-0142(19810301)47:5<889::aid-cncr2820470513>3.0.co;2-r.
2
Formation of ether-soluble Griess reagent-positive material from human feces and sodium nitrite.人粪便与亚硝酸钠形成醚溶性格里斯试剂阳性物质。
Environ Res. 1980 Dec;23(2):319-25. doi: 10.1016/0013-9351(80)90066-3.
3
General structure of "fecapentaenes"--the mutagenic substances in human faeces: a preliminary report.
Naturwissenschaften. 1982 Nov;69(11):557-8. doi: 10.1007/BF00463515.
4
Nitrite-induced volatile fecal mutagens: some preliminary studies.亚硝酸盐诱导的挥发性粪便诱变剂：一些初步研究。
Cancer. 1982 Apr 1;49(7):1405-8. doi: 10.1002/1097-0142(19820401)49:7<1405::aid-cncr2820490716>3.0.co;2-2.
5
Are nitrite and N-nitroso compounds in gastric juice risk factors for carcinoma in the operated stomach?胃液中的亚硝酸盐和N-亚硝基化合物是胃切除术后发生胃癌的危险因素吗？
Lancet. 1980 Apr 5;1(8171):727-9. doi: 10.1016/s0140-6736(80)91229-5.
6
Carcinoma of the gastric stump.残胃癌
Am J Surg. 1973 Jan;125(1):29-38. doi: 10.1016/0002-9610(73)90005-6.
7
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Proc Natl Acad Sci U S A. 1973 Mar;70(3):782-6. doi: 10.1073/pnas.70.3.782.
8
Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals.在沙门氏菌/微粒体试验中作为诱变剂的致癌物检测：300种化学物质的测定
Proc Natl Acad Sci U S A. 1975 Dec;72(12):5135-9. doi: 10.1073/pnas.72.12.5135.
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Volatile nitrosamines in normal human faeces.正常人粪便中的挥发性亚硝胺。
Nature. 1978 Nov 16;276(5685):280-1. doi: 10.1038/276280a0.
10
Nitrite and nitrate are formed by endogenous synthesis in the human intestine.
Science. 1978 Jun 30;200(4349):1487-9. doi: 10.1126/science.663630.