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[具有抗菌和抗真菌活性的石胆酸衍生物。IV]

[Derivatives of lithocholic acid with antibacterial and antifungal activity. IV].

作者信息

Bellini A M, Quaglio M P, Cavazzini G, Cecchenini R

出版信息

Farmaco Sci. 1984 Apr;39(4):305-15.

PMID:6723947
Abstract

A series of N-substituted amides of litocholic acid and some N-substituted derivatives of 3 alpha-hydroxy-24-amino-5 beta- cholane were prepared and their in vitro antibacterial and antifungal activity determined against a variety of gram-positive and gram-negative strains and two kinds of mycetes . Some of the tested compounds showed an interesting activity against gram-positive strains and mycetes .

摘要

制备了一系列石胆酸的N-取代酰胺以及3α-羟基-24-氨基-5β-胆烷的一些N-取代衍生物，并测定了它们对多种革兰氏阳性菌、革兰氏阴性菌以及两种霉菌的体外抗菌和抗真菌活性。一些受试化合物对革兰氏阳性菌和霉菌显示出有趣的活性。

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