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[具有抗菌和抗真菌活性的物质。VI。1,5 - 二芳基吡咯和1,4 - 吡咯亚苯基新衍生物的合成及微生物活性]

[Substances with antibacterial and antifungal activity. VI. Synthesis and microbiologic activity of new derivatives of 1,5-diarylpyrrole and 1,4-pyrrolphenylene].

作者信息

Porretta G C, Cerreto F, Fioravanti F, Biava M, Scalzo M, Fischetti M, Riccardi F

出版信息

Farmaco. 1989 Jan;44(1):51-63.

PMID:2742721
Abstract

New 1,5-diarylpyrrole and 1,4-pyrrolphenylene derivatives were prepared to study influence on the microbiological activity of an unsubstituted pyrrole nucleus or of a double identical molecular structure. Antimicrobial data in comparision with antifungal antibiotic pyrrolnitrin showed that all tested compounds exhibited very poor antifungal and antibacterial activity. Only some derivatives showed a selective activity against strains of Candida sp. and against strains of gram-positive or gram-negative bacteria.

摘要

制备了新型1,5 - 二芳基吡咯和1,4 - 吡咯亚苯基衍生物,以研究未取代吡咯核或双相同分子结构对微生物活性的影响。与抗真菌抗生素吡咯菌素相比的抗菌数据表明,所有测试化合物的抗真菌和抗菌活性都非常差。只有一些衍生物对白色念珠菌菌株以及革兰氏阳性或革兰氏阴性细菌菌株表现出选择性活性。

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