Crawford M A, Kittleson M D, Fink G D
J Am Vet Med Assoc. 1984 Apr 1;184(7):818-21.
Primary adipsia and defective osmoreceptor function were diagnosed in a 7-month-old female Miniature Schnauzer. Also, the dog was noted to be dehydrated and to have chronic hypernatremia. On multiple occasions the dog's urine osmolality: plasma osmolality was greater than 4. The dog had inappropriate responses to isoosmotic and hypertonic NaCl infusions. Chlorpropamide administration initiated water intake but the volume was insufficient to avoid hypernatremia. The chronic hypernatremia and dehydration were treated successfully by mixing the calculated maintenance fluid volume in canned food. At 25 months of age, the dog died several days after becoming dehydrated and severely hypernatremic. Astrogliosis and neuronal degeneration were noted in both the thalamic and hypothalamic regions, but were believed to be nonspecific degenerative lesions compatible with seizures and severe dehydration.
一只7个月大的雌性迷你雪纳瑞被诊断出患有原发性烦渴和渗透压感受器功能缺陷。此外，这只狗还出现脱水和慢性高钠血症。多次检测发现，该犬的尿渗透压：血浆渗透压大于4。该犬对等渗和高渗氯化钠输注有不适当反应。给予氯磺丙脲后开始饮水，但饮水量不足以避免高钠血症。通过将计算出的维持液量混入罐头食品中，成功治疗了慢性高钠血症和脱水。在25月龄时，这只狗在出现脱水和严重高钠血症几天后死亡。在丘脑和下丘脑区域均发现星形胶质细胞增生和神经元变性，但被认为是与癫痫发作和严重脱水相符的非特异性退行性病变。
