Curie K, Speller D C, Simpson R A, Stephens M, Cooke D I
J Hyg (Lond). 1978 Feb;80(1):115-23. doi: 10.1017/s0022172400053432.
In the 15 months, February 1976 to April 1977, more than 241 patients became colonized with a strain of Klebsiella aerogenes, capsular serotype K2, resistant to most antibiotics. Urinary tract infection was the most common clinical manifestation but bacteraemia and, occasionally, infections of other sites were encountered. The main reservoir of the epidemic klebsiella was the gut, urine and skin of colonized patients. Gut carriage among staff was very uncommon. The most susceptible patients were elderly males, with debilitating illnesses and urinary tract abnormalities, especially if they were catheterized or receiving antibiotics. Likely vehicles for spread were the hands of staff, and contaminated bedpans and urinals. Control measures were directed at these factors. At the end of April 1977 no new cases had occurred for 3 months in the ward in which the outbreak began, and which had been the main focus of infection, and only 5 patients in the affected hospitals were known to be colonized by the epidemic klebsiella.
在1976年2月至1977年4月的15个月里，超过241名患者感染了一株产气克雷伯菌，其荚膜血清型为K2，对大多数抗生素耐药。尿路感染是最常见的临床表现，但也出现了菌血症，偶尔还会出现其他部位的感染。流行的克雷伯菌的主要储存库是定植患者的肠道、尿液和皮肤。医护人员的肠道携带情况非常罕见。最易感的患者是老年男性，患有使人虚弱的疾病且有尿路异常，特别是如果他们插有导尿管或正在接受抗生素治疗。可能的传播媒介是医护人员的手以及被污染的便盆和尿壶。控制措施针对这些因素。1977年4月底，疫情爆发的病房（也是主要感染源）已有3个月未出现新病例，受影响医院中已知仅有5名患者被流行的克雷伯菌定植。
