采用放射免疫技术对感染和未感染人群中的布鲁氏菌IgG和IgM抗体进行检测。
Estimation of IgG and IgM brucella antibodies in infected and non-infected persons by a radioimmune technique.
作者信息
Hewitt W G, Payne D J
出版信息
J Clin Pathol. 1984 Jun;37(6):692-6. doi: 10.1136/jcp.37.6.692.
Abstract
Sera from 105 blood donors and eight patients with brucellosis were examined for anti-brucella IgG and IgM by a radioimmune technique. A pooled standard was used for comparison and evaluation. The upper limit of the 99% confidence interval on the mean of both immunoglobulin classes in blood donor sera was below 7 units/ml. Antibody response was shown in three acute, two relapsing, two chronic, and one asymptomatic cases. Values of up to 300 units/ml of both classes were found in the acute cases. Chronic sufferers showed lower concentrations of antibody. Relapsing cases showed increases comprising mainly IgG. The assay method, which shows general concordance with the results of conventional tests. is useful and measures individual immunoglobulin classes directly.
摘要
采用放射免疫技术检测了105名献血者和8名布鲁氏菌病患者血清中的抗布鲁氏菌IgG和IgM。使用混合标准品进行比较和评估。献血者血清中两种免疫球蛋白类别的均值99%置信区间上限低于7单位/毫升。在3例急性、2例复发、2例慢性和1例无症状病例中显示出抗体反应。急性病例中两种类别的抗体值高达300单位/毫升。慢性患者的抗体浓度较低。复发病例显示主要是IgG升高。该检测方法与传统检测结果总体一致，是有用的且可直接检测个体免疫球蛋白类别。
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