Gutteridge J M
Biochim Biophys Acta. 1985 Apr 25;834(2):144-8. doi: 10.1016/0005-2760(85)90149-3.
Haem and non-haem iron-containing proteins stimulate lipid peroxidation with the formation of fluorescent lipid complexes. This process requires the presence of lipid hydroperoxides which release ferrozine-reactive iron from haem-containing proteins. Stimulation of lipid peroxidation by the released iron is inhibited by the iron chelator desferrioxamine. Copper ions, although more stimulatory towards fluorescent lipid complex formation than iron ions, do not stimulate lipid peroxidation when tightly bound at the active centre of proteins, but are reactive when loosely bound to albumin and histidine.
血红素和非血红素含铁蛋白通过形成荧光脂质复合物刺激脂质过氧化。这个过程需要脂质氢过氧化物的存在，其从含血红素的蛋白质中释放出与亚铁嗪反应的铁。释放出的铁对脂质过氧化的刺激作用可被铁螯合剂去铁胺抑制。铜离子虽然比铁离子对荧光脂质复合物形成的刺激作用更强，但当紧密结合在蛋白质的活性中心时不会刺激脂质过氧化，而当松散结合于白蛋白和组氨酸时具有反应活性。
