Genedani S, Piccinini G, Bertolini A
Life Sci. 1984 Jun 11;34(24):2407-12. doi: 10.1016/0024-3205(84)90429-6.
Putrescine, intraperitoneally injected into rats at doses of 200, 300 and 400 mg/Kg, had a dose-dependent analgesic effect (hot plate, 55.5 degrees C), which was not antagonized by naloxone. Analgesia was also obtained by intracerebroventricular injection (1,000 nmoles/rat). Chronic administration (300 mg/Kg/day i.p. for 8 consecutive days) resulted in the development of tolerance. In our experimental conditions, no obvious toxicity was observed. These results may suggest for polyamines a role in nociception, and may disclose a new class of analgesic drugs.
以200、300和400毫克/千克的剂量腹腔注射给大鼠的腐胺具有剂量依赖性镇痛作用（热板法，55.5摄氏度），该作用不受纳洛酮拮抗。脑室内注射（1000纳摩尔/大鼠）也可产生镇痛效果。长期给药（300毫克/千克/天，腹腔注射，连续8天）会导致耐受性的产生。在我们的实验条件下，未观察到明显毒性。这些结果可能提示多胺在伤害感受中起作用，并可能揭示一类新的镇痛药。
