Genedani S, Bernardi M, Tagliavini S, Bertolini A
Life Sci. 1986 Apr 7;38(14):1293-8. doi: 10.1016/0024-3205(86)90422-4.
Intraperitoneal injection of putrescine induced dose-related hypothermia in rats. The effect was more pronounced at room temperature (22 degrees C) than in a warm environment (30 degrees C), the maximum hypothermia (-2.64 +/- 0.29 degrees C, 30 min. after treatment) being obtained with the dose of 300 mg/Kg and remaining significant throughout 3 hr of observation. Putrescine also had antipyretic activity, as it significantly reduced pyrogen-induced fever at a dose level (100 mg/Kg i.p.) ineffective in causing hypothermia in normal rats. The hypothermic and antipyretic effects of putrescine were not associated with any obvious sign of toxicity.
给大鼠腹腔注射腐胺可诱导剂量相关的体温过低。该效应在室温（22摄氏度）下比在温暖环境（30摄氏度）中更明显，在300毫克/千克剂量时可获得最大体温过低（治疗后30分钟时为-2.64±0.29摄氏度），并且在整个3小时的观察期内仍很显著。腐胺也具有解热活性，因为它在正常大鼠中不能引起体温过低的剂量水平（腹腔注射100毫克/千克）下能显著降低致热原诱导的发热。腐胺的体温过低和解热作用与任何明显的毒性迹象无关。
