Porter N A
Methods Enzymol. 1984;105:273-82. doi: 10.1016/s0076-6879(84)05035-7.
The free radical chemistry of lipid peroxidation is complex. The classical mechanism of autoxidation involving a peroxy radical abstracting hydrogen atom from lipid and oxygen addition to the carbon radical thus formed must be modified to include (1) peroxy radical beta fragmentation and (2) peroxy radical cyclization. A host of diene hydroperoxides, cyclic peroxides, bicyclic peroxides and epoxy alcohols may be formed in free fatty acid or phospholipid autoxidation. The distribution of products and the effects of hydrogen atom donors on product distribution are understandable by referring to a general scheme for autoxidation described in Scheme III and in Ref. 10.
脂质过氧化的自由基化学过程很复杂。涉及过氧自由基从脂质中提取氢原子并将氧加成到由此形成的碳自由基上的经典自氧化机制必须进行修正，以纳入(1)过氧自由基β断裂和(2)过氧自由基环化。在游离脂肪酸或磷脂自氧化过程中可能会形成一系列二烯氢过氧化物、环状过氧化物、双环过氧化物和环氧醇。通过参考方案III和参考文献10中描述的自氧化一般方案，可以理解产物的分布以及氢原子供体对产物分布的影响。
