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生物合成人生长激素对斯内尔侏儒小鼠和体外培养的中国仓鼠卵巢细胞的致断裂效应。

Clastogenic effects of biosynthetic human growth hormone in Snell dwarf mice and CHO cells in vitro.

作者信息

van Buul P P, van Buul-Offers S

出版信息

Mutat Res. 1984 Jun;127(1):61-4. doi: 10.1016/0027-5107(84)90140-4.

DOI:10.1016/0027-5107(84)90140-4
PMID:6727903
Abstract

Treatment of Snell dwarf mice with high concentrations of human growth hormone from pituitaries as well as of bacterial origin, significantly increased the frequencies of chromosomal aberrations in bone-marrow cells, as measured by the micronucleus test. In vitro treatment of Chinese hamster ovary (CHO) cells with the two types of hormone likewise induced structural chromosomal aberrations.

摘要

用来自垂体以及细菌来源的高浓度人生长激素治疗斯内尔侏儒小鼠，通过微核试验测量，显著增加了骨髓细胞中染色体畸变的频率。用这两种激素对中国仓鼠卵巢（CHO）细胞进行体外处理同样诱导了染色体结构畸变。

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