Morini S, Manurita L, Stroppa I, Bassi O
Minerva Med. 1984 Apr 21;75(17):963-6.
211 possibly neoplastic patients were given total colonoscopies after Hemoccult II test. The purpose of the experiment was to judge the value of occult faecal blood tests in the diagnosis of colonic neoplasias. Positive test results were obtained in 52 of whom 5 were found to have carcinomas and 17 polyps. Negative Hemoccult II results were produced in 159 patients of whom 6 had carcinomas and 54 polyps. All carcinoma patients with positive Hemoccult II results had rectal bleeding, 50% of those with negative tests results. Among polyp patients, 53% of those with Hemoccult II positive reported rectal bleeding, 60% of those with negative test results. Thus Hemoccult II is shown to be insufficiently sensitive to be of much value in mass screenings. It is suggested that a more sensitive test should be used for surveys of occult faecal blood.
211名可能患有肿瘤的患者在进行隐血II试验后接受了全结肠镜检查。该实验的目的是判断粪便潜血试验在结肠肿瘤诊断中的价值。52名患者检测结果呈阳性,其中5人患有癌症,17人患有息肉。159名患者隐血II检测结果为阴性,其中6人患有癌症,54人患有息肉。所有隐血II检测结果呈阳性的癌症患者都有直肠出血,检测结果为阴性的患者中有50%有直肠出血。在息肉患者中,隐血II检测结果呈阳性的患者中有53%报告有直肠出血,检测结果为阴性的患者中有60%有直肠出血。因此,隐血II在大规模筛查中显示出灵敏度不足,没有太大价值。建议使用更灵敏的检测方法来检测粪便潜血。