Dybdahl J H, Daae L N, Larsen S, Myren J
Scand J Gastroenterol. 1984 Mar;19(2):245-54.
In 67 patients referred for colonoscopy the faecal blood loss was determined by a 51Cr method and 7 chemical tests. For patients with negative colonoscopy (no. = 10), colorectal polyps (no. = 24), rectal cancer (no. = 8), or colonic cancer (no. = 12), the median 51Cr-determined faecal blood loss was 0.67, 0.74, 1.26, and 2.18 ml/24 h, respectively. For all chemical tests the results were highly influenced by the upper time limit for a positive reaction. Mixing of faecal specimens before testing proved unimportant. Fecatwin sensitive showed more positive tests in delayed compared with immediate analyses (p less than 0.01). Of cases of colorectal polyps, tetramethylbenzidine (TMB) tests including Hemo-Fec Test could detect half, the benzidine test 2 of 5. Fecatwin sensitive and Hemoccult II 1 of 4, and Fecatwin 1 of 24. Of cases of colorectal cancer, TMB tests, the benzidine test, Fecatwin sensitive, Hemoccult, and Fecatwin could detect about 85%, 85%, 85%, 80%, and 45%, respectively. All chemical tests detected faecal blood loss from colorectal lesions more easily than from gastric lesions.
在67例接受结肠镜检查的患者中，采用51Cr法和7种化学检测方法测定粪便失血量。对于结肠镜检查结果为阴性（n = 10）、患有大肠息肉（n = 24）、直肠癌（n = 8）或结肠癌（n = 12）的患者，51Cr法测定的粪便失血量中位数分别为0.67、0.74、1.26和2.18 ml/24小时。对于所有化学检测方法，结果都受到阳性反应的上限时间的高度影响。检测前粪便标本的混合被证明并不重要。与即时分析相比，Fecatwin sensitive在延迟分析中显示出更多的阳性检测结果（p < 0.01）。在大肠息肉病例中，包括Hemo-Fec Test在内的四甲基联苯胺（TMB）检测能检测出一半病例，联苯胺检测能检测出5例中的2例。Fecatwin sensitive和Hemoccult II能检测出4例中的1例，Fecatwin能检测出24例中的1例。在结肠癌病例中，TMB检测、联苯胺检测、Fecatwin sensitive、Hemoccult和Fecatwin分别能检测出约85%、85%、85%、80%和45%的病例。所有化学检测方法检测大肠病变导致的粪便失血比检测胃部病变导致的粪便失血更容易。
