De Cock C, Vermeij P, Stijnen T
Pharm Weekbl Sci. 1984 Apr 27;6(2):88-90. doi: 10.1007/BF01953960.
A prospective, double-blind investigation into the effectiveness of the addition to infusion fluids of an injectable containing 0.3 mg prednisolone and 10 units heparin per ml in a phosphate buffer pH = 7.5 versus the phosphate buffer alone is described. 196 Patients were allocated alternately to each group. On a total number of 593 cannulation days, 16 cases of thrombophlebitis were diagnosed. Statistical evaluation revealed a significant difference between the two groups (p less than 0.01) in favour of prednisolone + heparin sodium.
本文描述了一项前瞻性、双盲研究，旨在对比在pH = 7.5的磷酸盐缓冲液中，每毫升添加0.3毫克泼尼松龙和10单位肝素的注射剂与单独使用磷酸盐缓冲液添加到输液中的效果。196名患者被交替分配到每组。在总共593个置管日中，诊断出16例血栓性静脉炎。统计评估显示两组之间存在显著差异（p小于0.01），支持泼尼松龙 + 肝素钠组。
