双二烷基氨基膦的原位活化——一种在聚合物载体上合成脱氧寡核苷酸的新方法。
In situ activation of bis-dialkylaminophosphines--a new method for synthesizing deoxyoligonucleotides on polymer supports.
作者信息
Barone A D, Tang J Y, Caruthers M H
出版信息
Nucleic Acids Res. 1984 May 25;12(10):4051-61. doi: 10.1093/nar/12.10.4051.
Abstract
Deoxynucleoside phosphoramidites can be prepared in good yield from deoxynucleosides, bis- dialkylaminophosphines , and the corresponding dialkylamine hydrotetrazolide or tetrazole as catalysts. These phosphoramidites generated in situ lead to the direct synthesis of deoxyoligonucleotides on polymer supports.
摘要
脱氧核苷亚磷酰胺可以由脱氧核苷、双二烷基氨基膦以及相应的二烷基胺氢四唑化物或四唑作为催化剂以良好的产率制备。这些原位生成的亚磷酰胺可直接在聚合物载体上合成脱氧寡核苷酸。
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